p-p53 Antibody (FPS392): sc-56173
- p-p53 Antibody (FPS392) is a mouse monoclonal IgG1, cited in 6 publications, provided at 100 µg/ml
- raised against a C-terminal phosphopeptide corresponding to amino acids Ser 392 of p53 of human origin
- recommended for detection of Ser 392 phosphorylated p53 of mouse, rat, human, porcine and canine origin by WB, IP, IF, IHC(P) and ELISA; not recommended for detection of dephosphorylated p53
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for p-p53 Antibody (FPS392). This work is in progress.
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p-p53 Antibody (FPS392) is a mouse monoclonal IgG1 antibody that detects p53 in mouse, rat, human, porcine, and canine samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). p-p53 monoclonal antibody (FPS392) specifically recognizes the phosphorylated form of p53, a crucial tumor suppressor protein that plays a vital role in cellular responses to stress, including DNA damage. The phosphorylation of p53 enhances stability and transcriptional activity, allowing effective regulation of genes involved in cell cycle arrest and apoptosis. This post-translational modification is essential for p53 activation in response to cellular stress signals, ensuring damaged cells do not proliferate, which is a key mechanism in preventing tumorigenesis. Furthermore, p53′s ability to form tetramers and dynamic conformational changes are influenced by these phosphorylation events, underscoring the importance of post-translational modifications in functional regulation. With broad species reactivity and versatility in various applications, anti-p53 antibody (FPS392) is an invaluable tool for researchers studying p53′s intricate roles in cancer biology and cellular stress responses.
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p-p53 Antibody (FPS392) References:
- Effect of Boschniakia rossica on expression of GST-P, p53 and p21(ras)proteins in early stage of chemical hepatocarcinogenesis and its anti-inflammatory activities in rats. | Yin, ZZ., et al. 2000. World J Gastroenterol. 6: 812-818. PMID: 11819701
- Bcl-2 up-regulation and P-p53 down-regulation account for the low sensitivity of murine L929 fibrosarcoma cells to oridonin-induced apoptosis. | Huang, J., et al. 2005. Biol Pharm Bull. 28: 2068-74. PMID: 16272691
- Dimethylfumarate inhibits MIF-induced proliferation of keratinocytes by inhibiting MSK1 and RSK1 activation and by inducing nuclear p-c-Jun (S63) and p-p53 (S15) expression. | Gesser, B., et al. 2011. Inflamm Res. 60: 643-53. PMID: 21340650
- ATM mediates interdependent activation of p53 and ERK through formation of a ternary complex with p-p53 and p-ERK in response to DNA damage. | Heo, JI., et al. 2012. Mol Biol Rep. 39: 8007-14. PMID: 22576881
- MicroRNA Control of p53. | Liu, J., et al. 2017. J Cell Biochem. 118: 7-14. PMID: 27216701
- The ATM kinase inhibitor KU-55933 provides neuroprotection against hydrogen peroxide-induced cell damage via a γH2AX/p-p53/caspase-3-independent mechanism: Inhibition of calpain and cathepsin D. | Chwastek, J., et al. 2017. Int J Biochem Cell Biol. 87: 38-53. PMID: 28341201
- Activated mitochondrial apoptosis in hESCs after dissociation involving the PKA/p-p53/Bax signaling pathway. | Zhang, L., et al. 2018. Exp Cell Res. 369: 226-233. PMID: 29802837
- Recent Advances in p53. | D'Orazi, G. 2021. Biomolecules. 11: PMID: 33546313
- Nuclear HKII-P-p53 (Ser15) Interaction is a Prognostic Biomarker for Chemoresponsiveness and Glycolytic Regulation in Epithelial Ovarian Cancer. | Han, CY., et al. 2021. Cancers (Basel). 13: PMID: 34298618
- p53 and apoptosis. | Bellamy, CO. 1997. Br Med Bull. 53: 522-38. PMID: 9374035
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p-p53 Antibody (FPS392) | sc-56173 | 100 µg/ml | $322.00 |