p-c-Abl Antibody (7.Tyr 412): sc-293130

p-c-Abl Antibody (7.Tyr 412) is a mouse monoclonal IgG2a kappa light chain antibody that detects Tyr 412 phosphorylated c-Abl of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). anti-p-c-Abl antibody (7.Tyr 412) is available in both conjugated and non-conjugated forms, providing flexibility for various experimental needs. c-Abl plays a crucial role in cellular signaling pathways, particularly in regulating cell growth and differentiation, making c-Abl a significant factor in oncogenesis. Tyrosine kinase activity of c-Abl is essential for mediating signals that influence cell cycle progression and apoptosis. Dysregulation of c-Abl, often due to chromosomal translocations such as the (9;22) translocation that produces the Philadelphia chromosome, can lead to several types of leukemia, including chronic myelocytic leukemia and acute lymphoblastic leukemia. The presence of activated Bcr/c-Abl fusion protein, resulting from this translocation, further underscores c-Abl′s importance in cancer biology, as Bcr/c-Abl contributes to uncontrolled proliferation of leukemic cells. p-c-Abl monoclonal antibody (7.Tyr 412) enables valuable insights into c-Abl′s role in these malignancies and exploration of potential therapeutic targets.

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p-c-Abl Antibody (7.Tyr 412) References:

1. Three-dimensional solution structure of the src homology 2 domain of c-abl.  |  Overduin, M., et al. 1992. Cell. 70: 697-704. PMID: 1505033
2. Bcr encodes a GTPase-activating protein for p21rac.  |  Diekmann, D., et al. 1991. Nature. 351: 400-2. PMID: 1903516
3. c-Abl phosphorylation primes PARIS for neurodegeneration.  |  Giesert, F. 2021. Brain. 144: 3555-3557. PMID: 34788407
4. c-Abl Regulates the Pathological Deposition of TDP-43 via Tyrosine 43 Phosphorylation.  |  Lee, S., et al. 2022. Cells. 11: PMID: 36552734
5. c-Abl Phosphorylates MFN2 to Regulate Mitochondrial Morphology in Cells under Endoplasmic Reticulum and Oxidative Stress, Impacting Cell Survival and Neurodegeneration.  |  Martinez, A., et al. 2023. Antioxidants (Basel). 12: PMID: 38001860
6. Evidence of a new chimeric bcr/c-abl mRNA in patients with chronic myelocytic leukemia and the Philadelphia chromosome.  |  Stam, K., et al. 1985. N Engl J Med. 313: 1429-33. PMID: 3864009
7. Lymphosarcoma: virus-induced thymic-independent disease in mice.  |  Abelson, HT. and Rabstein, LS. 1970. Cancer Res. 30: 2213-22. PMID: 4318922
8. Sequences of the A-MuLV protein needed for fibroblast and lymphoid cell transformation.  |  Prywes, R., et al. 1983. Cell. 34: 569-79. PMID: 6193890
9. An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity.  |  Konopka, JB., et al. 1984. Cell. 37: 1035-42. PMID: 6204766
10. A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia.  |  de Klein, A., et al. 1982. Nature. 300: 765-7. PMID: 6960256

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-p-c-Abl Antibody (7.Tyr 412) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-p-c-Abl Antibody (7.Tyr 412) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

p-c-Abl Antibody (7.Tyr 412) Specifications

Alternate Product Name: ABL1

Product Clone Name: 7.Tyr 412

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: Tyr 412

Epitope Target: c-Abl

Epitope Species: human

Product Reactivity/Detection: Tyr 412 phosphorylated c-Abl

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for p-c-Abl Antibody (7.Tyr 412): AC: Agarose, HRP: Horseradish Peroxidase

The preferred c-Abl antibody is c-Abl Antibody (24-11): sc-23.