p-B-Myb Antibody H-3 è un monoclonale di topo IgG2b fornito in 200 µg/ml
p-B-Myb Antibody (H-3) é raccomandato per il rilevamento di Thr 490 phosphorylated B-Myb di origine mouse, rat, human e in WB, IP, IF and ELISA; anche reattivo con ulteriori specie, incluse e equine, canine, bovine, porcine and avian
p-B-Myb Antibody (H-3) é disponibile coniugato con agarose per IP; HRP per WB, IHC(P) ed ELISA; sia con phycoerythrin o FITC per IF, IHC(P) e FCM
disponibile anche coniugato con Alexa Fluor® 488, Alexa Fluor® 546; Alexa Fluor® 594 o Alexa Fluor® 647 per IF, IHC (P) e FCM
disponibile anche coniugato con Alexa Fluor® 680 o Alexa Fluor® 790 per WB (NIR), IF e FCM
Contattaci per ricevere un FREE 10 µg sample di p-B-Myb (H-3): sc-377500.
m-IgG Fc BP-HRP and m-IgG2b BP-HRP are the preferred secondary detection reagents for p-B-Myb Antibody (H-3) for WB applications. These reagents are now offered in bundles with p-B-Myb Antibody (H-3) (see ordering information below).
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
A member of the myb proto-oncogene family, B-Myb is a cell cycle-regulated transcription factor that is essential for the transition from G1 to S phase. This nuclear protein becomes phosphorylated at the onset of S phase by the cyclin A/Cdk2 complex. Ten phosphorylation sites have been identified and all sites were on either serine or threonine residues that were followed by a proline residue, suggesting that phosphorylation is due to a proline-directed kinase. Transactivation properties of B-Myb are apparently dependent upon the protein′s hyperphosphorylation. Several phosphorylation sites, including threonine 447, threonine 490, threonine 497 and serine 581, are located near the protein′s C-terminus. Phosphorylation of these C-terminal residues plays a critical role in enhancing the transcriptional activity of B-Myb. Poly(ADP-ribose) polymerase (PARP), which has a role in cellular proliferation, binds to B-Myb and thus enhances B-Myb transactivation. PARP is a B-Myb co-factor and promotes phosphorylation of B-Myb by the Cyclin/Cdk2 complex.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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