oligophrenin-1 Antibody (G-6): sc-376038

Oligophrenin-1 Antibody (G-6) is a mouse monoclonal IgG2b antibody that detects oligophrenin-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Oligophrenin-1 plays a crucial role as a RhoGAP protein, stimulating the GTP hydrolysis of Rho subfamily members, which is essential for regulating various cellular processes including cell migration, morphogenesis, and axon outgrowth. Anti-oligophrenin-1 antibody (G-6) influences the dynamics of the cytoskeleton and cellular signaling pathways that are vital for proper neuronal connectivity and plasticity. By facilitating the hydrolysis of GTP, oligophrenin-1 helps maintain the balance between active and inactive Rho proteins, thereby ensuring that cellular responses to external stimuli are appropriately regulated. Oligophrenin-1 (G-6) antibody serves as an invaluable tool for researchers investigating the intricate mechanisms of cell signaling and development, particularly in studies related to neurobiology and cancer research.

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oligophrenin-1 Antibody (G-6) References:

1. Deletion including the oligophrenin-1 gene associated with enlarged cerebral ventricles, cerebellar hypoplasia, seizures and ataxia.  |  Tentler, D., et al. 1999. Eur J Hum Genet. 7: 541-8. PMID: 10439959
2. Determination of the gene structure of human oligophrenin-1 and identification of three novel polymorphisms by screening of DNA from 164 patients with non-specific X-linked mental retardation.  |  Billuart, P., et al. 2000. Ann Genet. 43: 5-9. PMID: 10818214
3. Significant overexpression of oligophrenin-1 in colorectal tumors detected by cDNA microarray analysis.  |  Pinheiro, NA., et al. 2001. Cancer Lett. 172: 67-73. PMID: 11595131
4. Mutations in the oligophrenin-1 gene (OPHN1) cause X linked congenital cerebellar hypoplasia.  |  Philip, N., et al. 2003. J Med Genet. 40: 441-6. PMID: 12807966
5. Evidence that a major site of expression of the RHO-GTPASE activating protein, oligophrenin-1, is peripheral myelin.  |  Xiao, J., et al. 2004. Neuroscience. 124: 781-7. PMID: 15026118
6. The X-linked mental retardation protein oligophrenin-1 is required for dendritic spine morphogenesis.  |  Govek, EE., et al. 2004. Nat Neurosci. 7: 364-72. PMID: 15034583
7. Rho Kinase Inhibition Is Essential During In Vitro Neurogenesis and Promotes Phenotypic Rescue of Human Induced Pluripotent Stem Cell-Derived Neurons With Oligophrenin-1 Loss of Function.  |  Compagnucci, C., et al. 2016. Stem Cells Transl Med. 5: 860-9. PMID: 27160703
8. Protein Kinase A Deregulation in the Medial Prefrontal Cortex Impairs Working Memory in Murine Oligophrenin-1 Deficiency.  |  Zhang, CL., et al. 2017. J Neurosci. 37: 11114-11126. PMID: 29030432
9. ROCK/PKA Inhibition Rescues Hippocampal Hyperexcitability and GABAergic Neuron Alterations in a Oligophrenin-1 Knock-Out Mouse Model of X-Linked Intellectual Disability.  |  Busti, I., et al. 2020. J Neurosci. 40: 2776-2788. PMID: 32098904
10. Oligophrenin 1 encodes a rho-GAP protein involved in X-linked mental retardation.  |  Billuart, P., et al. 1998. Pathol Biol (Paris). 46: 678. PMID: 9885813

The preferred oligophrenin-1 antibody is oligophrenin-1 Antibody (A-12): sc-374330.