oligophrenin-1 Antibody (D-2): sc-376640

Oligophrenin-1 Antibody (D-2) is a mouse monoclonal IgG1 antibody that detects oligophrenin-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Oligophrenin-1 plays a crucial role as a RhoGAP protein, stimulating the hydrolysis of GTP bound to Rho subfamily members, which is essential for regulating various cellular processes including cell migration, morphogenesis, and axon outgrowth. Anti-oligophrenin-1 antibody (D-2) influences the dynamics of the cytoskeleton and cellular signaling pathways that are vital for proper neuronal connectivity and plasticity. By facilitating GTP hydrolysis, oligophrenin-1 helps maintain the balance between active and inactive Rho proteins, thereby ensuring that cellular responses to external stimuli are appropriately regulated. Oligophrenin-1 (D-2) antibody serves as an invaluable tool for researchers investigating the intricate mechanisms of cell signaling and development, particularly in studies focused on neurobiology and related fields.

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oligophrenin-1 Antibody (D-2) References:

1. Oligophrenin 1 mutations frequently cause X-linked mental retardation with cerebellar hypoplasia.  |  Zanni, G., et al. 2005. Neurology. 65: 1364-9. PMID: 16221952
2. Association of syndromic mental retardation with an Xq12q13.1 duplication encompassing the oligophrenin 1 gene.  |  Bedeschi, MF., et al. 2008. Am J Med Genet A. 146A: 1718-24. PMID: 18512229
3. Rapid synthesis of the X-linked mental retardation protein OPHN1 mediates mGluR-dependent LTD through interaction with the endocytic machinery.  |  Nadif Kasri, N., et al. 2011. Neuron. 72: 300-15. PMID: 22017989
4. The X-linked mental retardation protein OPHN1 interacts with Homer1b/c to control spine endocytic zone positioning and expression of synaptic potentiation.  |  Nakano-Kobayashi, A., et al. 2014. J Neurosci. 34: 8665-71. PMID: 24966368
5. Rho Kinase Inhibition Is Essential During In Vitro Neurogenesis and Promotes Phenotypic Rescue of Human Induced Pluripotent Stem Cell-Derived Neurons With Oligophrenin-1 Loss of Function.  |  Compagnucci, C., et al. 2016. Stem Cells Transl Med. 5: 860-9. PMID: 27160703
6. Protein Kinase A Deregulation in the Medial Prefrontal Cortex Impairs Working Memory in Murine Oligophrenin-1 Deficiency.  |  Zhang, CL., et al. 2017. J Neurosci. 37: 11114-11126. PMID: 29030432
7. A novel intragenic deletion in OPHN1 in a Japanese patient with Dandy-Walker malformation.  |  Iida, A., et al. 2019. Hum Genome Var. 6: 1. PMID: 30534410
8. ROCK/PKA Inhibition Rescues Hippocampal Hyperexcitability and GABAergic Neuron Alterations in a Oligophrenin-1 Knock-Out Mouse Model of X-Linked Intellectual Disability.  |  Busti, I., et al. 2020. J Neurosci. 40: 2776-2788. PMID: 32098904
9. Ophn1 regulation of prefrontal inhibition: A mechanism for stress susceptibility in intellectual disability.  |  Cvetkovska, V. and Bagot, RC. 2021. Neuron. 109: 1583-1584. PMID: 34015262
10. Targeting the Lnc-OPHN1-5/androgen receptor/hnRNPA1 complex increases Enzalutamide sensitivity to better suppress prostate cancer progression.  |  Zhang, M., et al. 2021. Cell Death Dis. 12: 855. PMID: 34545067

The preferred oligophrenin-1 antibody is oligophrenin-1 Antibody (A-12): sc-374330.