Molecular structure of Nystatin, CAS Number: 1400-61-9
Nystatin (CAS 1400-61-9)
See product citations (7)
Alternate Names:
Fungicidin; Mycostatin
Application:
Nystatin is a polyene antifungal and antibiotic which increases membrane permeability
CAS Number:
1400-61-9
Molecular Weight:
926.09
Molecular Formula:
C47H75NO17
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Nystatin is a polyene antifungal compound that functions by binding to ergosterol in the fungal cell membrane, leading to the formation of pores and ultimately causing the leakage of intracellular contents. This disrupts the integrity of the fungal cell membrane, resulting in cell death. Nystatin′s mechanism of action involves its ability to selectively target ergosterol, a key component of the fungal cell membrane, without affecting the cholesterol in mammalian cell membranes. This specificity allows nystatin to exert its antifungal activity with minimal impact on mammalian cells. By disrupting the fungal cell membrane, nystatin effectively inhibits the growth and proliferation of a wide range of pathogenic fungi, making it a valuable tool for studying fungal biology and developing potential antifungal strategies.
Nystatin (CAS 1400-61-9) References
- Two mutants selectively resistant to polyenes reveal distinct mechanisms of antifungal activity by nystatin and amphotericin B. | Hapala, I., et al. 2005. Biochem Soc Trans. 33: 1206-9. PMID: 16246082
- Structural analysis and biosynthetic engineering of a solubility-improved and less-hemolytic nystatin-like polyene in Pseudonocardia autotrophica. | Lee, MJ., et al. 2012. Appl Microbiol Biotechnol. 95: 157-68. PMID: 22382166
- Nystatin and miconazole: pharmacological and clinical evidence regarding interactions with warfarin. | Pemberton, MN. 2016. Oral Dis. 22: 761-765. PMID: 27416928
- Nystatin antifungal micellar systems on endotracheal tubes: development, characterization and in vitro evaluation. | Benavent, C., et al. 2019. Pharmazie. 74: 34-38. PMID: 30782248
- Nystatin Regulates Axonal Extension and Regeneration by Modifying the Levels of Nitric Oxide. | Roselló-Busquets, C., et al. 2020. Front Mol Neurosci. 13: 56. PMID: 32317932
- Antifungal activity of Punicalagin-nystatin combinations against Candida albicans. | da Silva, RA., et al. 2020. Oral Dis. 26: 1810-1819. PMID: 32583467
- Direct observation of nystatin binding to the plasma membrane of living cells. | Szomek, M., et al. 2021. Biochim Biophys Acta Biomembr. 1863: 183528. PMID: 33279513
- Efficacy of different formulations of nystatin in an experimental model of oral candidiasis in sialoadenectomized rats. | Pérez-Sayáns, M., et al. 2021. J Dent Sci. 16: 123-130. PMID: 33384788
- Nystatin effect on chlorhexidine efficacy against Streptococcus mutans as planktonic cells and mixed biofilm with Candida albicans. | Baldino, MEL., et al. 2022. Clin Oral Investig. 26: 633-642. PMID: 34160701
- Synergistic effect of thymoquinone and nystatin in the treatment of oral candidiasis; an in vitro study. | Özdal Zincir, Ö., et al. 2022. Odontology. 110: 330-337. PMID: 34657217
- Design of transfersomal nanocarriers of nystatin for combating vulvovaginal candidiasis; A different prospective. | Hady, MA., et al. 2022. Colloids Surf B Biointerfaces. 211: 112304. PMID: 34959094
- Water-Soluble Nystatin and Derivative. | Amir, A., et al. 2022. ACS Med Chem Lett. 13: 182-187. PMID: 35178173
- Effect of nystatin and licorice on yeasts isolated from the oral lesions of patients with cancer under chemotherapy (in vitro study). | Khozeimeh, F., et al. 2022. Dent Res J (Isfahan). 19: 61. PMID: 36159062
- Effect of Nystatin on Candida albicans - Streptococcus mutans duo-species biofilms. | Alomeir, N., et al. 2023. Arch Oral Biol. 145: 105582. PMID: 36395564
- Comparison of Antifungal Activity of Jaftex Mouthwash and Nystatin Suspension against the Growth of Candida albicans. | Amin, M., et al. 2022. Maedica (Bucur). 17: 647-653. PMID: 36540599
Inhibitor of:
2810008M24Rik, 4930538K18Rik, 4932438H23Rik, 5430405G05Rik, 8D6, AP1S2, apoF, ATP6V0E2, C8orf40, Candida albicans, caveolin-1, caveolin-2, CCDC132, Cdc50A, claudin 13, CRS1C-3, CTAGE4, CTAGE9, E030010A14Rik, EG434008, FCHO2, GLIPR1L1, Glycophorin D, Gm364, Gm889, HMG-1, hole, IFITM5, LAMP-5, LDLRAD4, LIMP III, LOC388564, LOC643008, MANSC4, Olfr782, Olfr784, Olfr907, Rab11-FIP5, Rotavirus, SERINC1, SH3YL1, SMAGP, SNX33, TLR13, TM6SF1, TMEM118, TMEM168, TMEM200C, Tmem210, TMEM213, TMEM233, TMEM34, TMEM52, TMEM93, TMEM95, TMEM99, TMEM9B, TSPAN11, TSPAN7, UHRF1BP1, UNQ830, and XKR4.Activator of:
α-Adaptin 1, Baculovirus gp64, C17orf59, C9orf91, COTE1, DC-SIGN_CD209a, epsin, epsin 4, LEPROT, MANSC4, MENTHO, MFSD8, NBEAL1, NECAP 1, OSBP2, PIS1, PRA1, RIN2, Syntabulin, TM7SF3, and TSPAN6.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nystatin, 5 MU | sc-212431 | 5 MU | $51.00 | |||
Nystatin, 25 MU | sc-212431A | 25 MU | $129.00 | |||
Nystatin, 250 MU | sc-212431B | 250 MU | $251.00 | |||
Nystatin, 5000 MU | sc-212431C | 5000 MU | $3570.00 |