Novobiocin Sodium Salt CAS: 1476-53-5
MF: C31H35N2O11•Na
MW: 634.6
An Hsp90 and DNA gyrase inhibitor.

Novobiocin Sodium Salt (CAS 1476-53-5)

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Novobiocin Sodium Salt is rated 4.5 out of 5 by 2.
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Nomi alternativi: Albamycin; Cathomycin sodium
Applicazione: Novobiocin Sodium Salt is an Hsp90 and DNA gyrase inhibitor
Numero CAS: 1476-53-5
Purezza: ≥95%
Peso molecolare: 634.6
Formula molecolare: C31H35N2O11•Na
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).

Novobiocin Sodium (U-6591) is a small molecule inhibitor of eukaryotic Topo II (DNA topoisomerase II) and prokaryotic DNA gyrase. In the case of DNA gyrase inhibition, Novobiocin functions as a competitive inhibitor of the ATP binding event necessary for turnover of the enzyme after a manipulation of DNA supercoils. Inhibition of these enzymes blocks the mechanism for detangling DNA and establishing the proper super-coiled state necessary for normal replication and transcription, compromising the viability of the cell. Treatment with Novobiocin is shown to potentiate the cytotoxic effects of DNA alkylating agents. Novobiocin is also described to inhibit DNA Polymerase (retroviral RNA-dependent DNA polymerase). Novobiocin is an inhibitor of Hsp90. Novobiocin interacts with the C-terminal ATP-binding domain of Hsp90. Novobiocin Sodium (U-6591) is an inhibitor of ABCG2.


Referenze

1. Sugino, A., et al. 1978. Proc. Natl. Acad. Sci. U.S.A. 75: 4838-4842. PMID: 368801
2. Cozzarelli, N.R. 1980. Science. 207: 953-960. PMID: 6243420
3. Sumiyoshi, Y., et al. 1983. J. Gen. Virol. 64: 2329-2333. PMID: 6311959
4. Lockshon, D., et al. 1983. Nucleic Acids Res. 11: 2999-3017. PMID: 6304617
5. Liebart, J.C., et al. 1989. Mol. Microbiol. 3: 269-273. PMID: 2546002
6. Ellis, G.K., et al. 1991. Cancer. 67: 2969-2973. PMID: 1646065
7. Kapiszewska, M., et al. 1991. Radiat. Res. 127: 285-291. PMID: 1886984
8. Kampranis, S.C, et al. 1996. Proc. Natl. Acad. Sci. U.S.A. 93: 14416-14421. PMID: 8962066

Formulazione :
potency: ~900 µg/mg
Stato fisico :
Solid
Solubilità :
Soluble in water (100 mg/ml), ethanol, DMSO, alcohol (1:7), and methanol (1:3).
CONSERVAZIONE :
Store at -20° C
Punto di scioglimento :
215° C
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
WGK Germania :
2
RTECS :
RD5425000
PubChem CID :
Indice Merck :
14: 6722
Numero MDL :
MFCD00066541
Numero EC :
216-023-6
Registro Beilstein :
3892910
SMILES :
CC1=C(C=CC2=C1OC(=O)C(=C2[O-])NC(=O)C3=CC(=C(C=C3)O)CC=C(C)C)OC4C(C(C(C(O4)(C)C)OC)OC(=O)N)O.[Na+]

Download SDS (MSDS)

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