NMNAT-3 Antibody (B-9): sc-398848

NMNAT-3 Antibody (B-9) is a mouse monoclonal IgG1 antibody that detects NMNAT-3 in mouse samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NMNAT-3, also known as nicotinamide mononucleotide adenylyltransferase 3, is a crucial enzyme in the synthesis of NAD+, a vital cofactor in cellular metabolism that plays a significant role in energy production and maintaining cellular health. This 252 amino acid protein is predominantly localized in the mitochondria, where NMNAT-3 participates in essential metabolic processes, underscoring NMNAT-3′s importance in energy homeostasis and cellular signaling. NMNAT-3′s presence in the mitochondria suggests a direct involvement in mitochondrial function and regulation of metabolic pathways critical for cell survival and function. Additionally, NMNAT-3 can form homotetramers and is highly expressed in tissues such as the spleen and lungs, indicating NMNAT-3′s potential role in immune responses and respiratory functions. With two isoforms resulting from alternative splicing, NMNAT-3′s diverse functional capabilities make NMNAT-3 a key player in cellular metabolism, and anti-NMNAT-3 antibody (B-9) is an invaluable tool for researchers studying NMNAT-3′s role in various biological processes.

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NMNAT-3 Antibody (B-9) References:

1. Axonal protection by Nmnat3 overexpression with involvement of autophagy in optic nerve degeneration.  |  Kitaoka, Y., et al. 2013. Cell Death Dis. 4: e860. PMID: 24136224
2. Insight into molecular and functional properties of NMNAT3 reveals new hints of NAD homeostasis within human mitochondria.  |  Felici, R., et al. 2013. PLoS One. 8: e76938. PMID: 24155910
3. Deficiency of nicotinamide mononucleotide adenylyltransferase 3 (nmnat3) causes hemolytic anemia by altering the glycolytic flow in mature erythrocytes.  |  Hikosaka, K., et al. 2014. J Biol Chem. 289: 14796-811. PMID: 24739386
4. Nmnat3 Is Dispensable in Mitochondrial NAD Level Maintenance In Vivo.  |  Yamamoto, M., et al. 2016. PLoS One. 11: e0147037. PMID: 26756334
5. NMNAT3 is involved in the protective effect of SIRT3 in Ang II-induced cardiac hypertrophy.  |  Yue, Z., et al. 2016. Exp Cell Res. 347: 261-73. PMID: 27423420
6. Restoration of Mitochondrial NAD+ Levels Delays Stem Cell Senescence and Facilitates Reprogramming of Aged Somatic Cells.  |  Son, MJ., et al. 2016. Stem Cells. 34: 2840-2851. PMID: 27428041
7. NMNAT3 is protective against the effects of neonatal cerebral hypoxia-ischemia.  |  Galindo, R., et al. 2017. Ann Clin Transl Neurol. 4: 722-738. PMID: 29046881
8. Overexpression of Nmnat3 efficiently increases NAD and NGD levels and ameliorates age-associated insulin resistance.  |  Gulshan, M., et al. 2018. Aging Cell. 17: e12798. PMID: 29901258
9. Nmnat3 deficiency in hemolytic anemia exacerbates malaria infection.  |  Mahmood, A., et al. 2022. Biochem Biophys Res Commun. 637: 58-65. PMID: 36375251
10. Nicotinamide mononucleotide combined with PJ-34 protects microglial cells from lipopolysaccharide-induced mitochondrial impairment through NMNAT3-PARP1 axis.  |  Li, J., et al. 2025. J Transl Med. 23: 279. PMID: 40050860

The preferred NMNAT-3 antibody is NMNAT-3 Antibody (D-10): sc-390433.