NGFR p75 Antibody (NGFR5): sc-58567
- NGFR p75 Antibody (NGFR5) is a mouse monoclonal IgG1 κ, cited in 6 publications, provided at 200 µg/ml
- raised against NGFR p75 from A875 melanoma cells of human origin
- recommended for detection of NGFR p75 of human and feline origin by WB, IP, IF, IHC(P) and FCM; non cross-reactive with mouse or rat NGFR p75
- See NGFR p75 (B-1): sc-271708 for NGFR p75 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for NGFR p75 Antibody (NGFR5) for WB and IHC(P) applications. These reagents are now offered in bundles with NGFR p75 Antibody (NGFR5) (see ordering information below).
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NGFR p75 Antibody (NGFR5) is a mouse monoclonal IgG1 antibody that detects NGFR p75 in human and feline samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). NGFR p75, also known as the low-affinity nerve growth factor receptor, plays a crucial role in the nervous system by modulating the effects of neurotrophic factors, particularly nerve growth factor (NGF). NGFR p75 is primarily located on the surface of neurons and glial cells, where NGFR p75 acts as a co-receptor that enhances the signaling of Trk receptors, such as Trk A. Anti-NGFR p75 antibody (NGFR5) is essential for studying efficient activation of Trk A, as NGFR p75 accelerates the receptor′s activation and facilitates the recruitment of downstream signaling molecules, thereby amplifying the neurotrophic response. This interaction is vital for neuronal survival, differentiation, and the maintenance of neuronal health, making NGFR p75 a significant player in neurobiology and a potential target for therapeutic interventions in neurodegenerative diseases. NGFR p75 monoclonal antibody (NGFR5) serves as an invaluable tool for researchers studying these critical pathways in both human and feline models.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
NGFR p75 Antibody (NGFR5) References:
- Diverse functions of the p75 neurotrophin receptor. | Yamashita, T., et al. 2005. Anat Sci Int. 80: 37-41. PMID: 15794129
- Diagnostic utility of p75 neurotrophin receptor (p75NTR) as a marker of breast myoepithelial cells. | Popnikolov, NK., et al. 2005. Mod Pathol. 18: 1535-41. PMID: 16258511
- Proneurotrophin Binding to P75 Neurotrophin Receptor (P75ntr) Is Essential for Brain Lesion Formation and Functional Impairment after Experimental Traumatic Brain Injury. | Sebastiani, A., et al. 2015. J Neurotrauma. 32: 1599-607. PMID: 25879397
- p75 Neurotrophin Receptor Regulates Energy Balance in Obesity. | Baeza-Raja, B., et al. 2016. Cell Rep. 14: 255-68. PMID: 26748707
- Neurotrophin Receptor p75NTR Regulates Immune Function of Plasmacytoid Dendritic Cells. | Bandoła, J., et al. 2017. Front Immunol. 8: 981. PMID: 28861085
- The p75 neurotrophin receptor enhances HIF-dependent signaling in glioma. | Tong, B., et al. 2018. Exp Cell Res. 371: 122-129. PMID: 30092219
- Schwann cell p75 neurotrophin receptor modulates small fiber degeneration in diabetic neuropathy. | Gonçalves, NP., et al. 2020. Glia. 68: 2725-2743. PMID: 32658363
- Towards a comprehensive understanding of p75 neurotrophin receptor functions and interactions in the brain. | Ritala, JF., et al. 2022. Neural Regen Res. 17: 701-704. PMID: 34472454
- Human immunomodulatory ligand B7-1 mediates synaptic remodeling via the p75 neurotrophin receptor. | Morano, NC., et al. 2022. J Clin Invest. 132: PMID: 36107635
- Modulation of p75 neurotrophin receptor mitigates brain damage following ischemic stroke in mice. | Mirzahosseini, G. and Ishrat, T. 2024. Neural Regen Res. 19: 2093-2094. PMID: 38488534
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NGFR p75 Antibody (NGFR5) | sc-58567 | 200 µg/ml | $322.00 | |||
NGFR p75 Antibody (NGFR5): m-IgG Fc BP-HRP Bundle | sc-539085 | 200 µg Ab; 10 µg BP | $361.00 | |||
NGFR p75 Antibody (NGFR5): m-IgG1 BP-HRP Bundle | sc-541249 | 200 µg Ab; 20 µg BP | $361.00 |