NGFR p75 Antibody (0.N.469): sc-71695
- NGFR p75 Antibody (0.N.469) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against NGFR p75 from A875 melanoma cells of human origin
- recommended for detection of NGFR p75 of human and feline origin by WB, IP, IF, IHC(P) and FCM; non cross-reactive with mouse or rat NGFR p75
- See NGFR p75 (B-1): sc-271708 for NGFR p75 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for NGFR p75 Antibody (0.N.469) for WB and IHC(P) applications. These reagents are now offered in bundles with NGFR p75 Antibody (0.N.469) (see ordering information below).
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NGFR p75 Antibody (0.N.469) is a mouse monoclonal IgG1 antibody that detects NGFR p75 in human and feline samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). NGFR p75, also known as the low-affinity nerve growth factor receptor, plays a crucial role in the nervous system by modulating the effects of neurotrophic factors, particularly in neuronal survival and differentiation. NGFR p75 is primarily located on the surface of neurons and glial cells, where NGFR p75 acts as a co-receptor for neurotrophins, enhancing the signaling of high-affinity receptors like TrkA. NGFR p75 is essential for the proper functioning of neurotrophic signaling pathways, as NGFR p75 not only facilitates the binding of neurotrophins but also influences the downstream signaling cascades vital for neuronal health and development. By understanding NGFR p75′s role in these processes, researchers can gain insights into neurodegenerative diseases and potential therapeutic targets. Anti-NGFR p75 antibody (0.N.469) is an invaluable tool for studying these mechanisms in both human and feline models, providing a reliable means to explore the intricate dynamics of neurotrophic signaling.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
NGFR p75 Antibody (0.N.469) References:
- The role of neurotransmission and the Chopper domain in p75 neurotrophin receptor death signaling. | Coulson, EJ., et al. 2004. Prog Brain Res. 146: 41-62. PMID: 14699955
- The p75 neurotrophin receptor enhances TrkA signalling by binding to Shc and augmenting its phosphorylation. | Epa, WR., et al. 2004. J Neurochem. 89: 344-53. PMID: 15056278
- Cleavage of p75 neurotrophin receptor by alpha-secretase and gamma-secretase requires specific receptor domains. | Zampieri, N., et al. 2005. J Biol Chem. 280: 14563-71. PMID: 15701642
- The p75 neurotrophin receptor in human development and disease. | Schor, NF. 2005. Prog Neurobiol. 77: 201-14. PMID: 16297524
- Modulation of semaphorin3A activity by p75 neurotrophin receptor influences peripheral axon patterning. | Ben-Zvi, A., et al. 2007. J Neurosci. 27: 13000-11. PMID: 18032673
- p75 neurotrophin receptor regulates agonist-induced pulmonary vasoconstriction. | Xu, M., et al. 2008. Am J Physiol Heart Circ Physiol. 295: H1529-38. PMID: 18689502
- Structural basis of death domain signaling in the p75 neurotrophin receptor. | Lin, Z., et al. 2015. Elife. 4: e11692. PMID: 26646181
- Reversal of Cognitive Impairment in gp120 Transgenic Mice by the Removal of the p75 Neurotrophin Receptor. | Speidell, A., et al. 2019. Front Cell Neurosci. 13: 398. PMID: 31543761
- Sexual Dimorphism in Balance and Coordination in p75NTRexonIII Knock-Out Mice. | Abbasian, M., et al. 2022. Front Behav Neurosci. 16: 842552. PMID: 35283743
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NGFR p75 Antibody (0.N.469) | sc-71695 | 200 µg/ml | $322.00 | |||
NGFR p75 Antibody (0.N.469): m-IgG Fc BP-HRP Bundle | sc-539393 | 200 µg Ab; 10 µg BP | $361.00 | |||
NGFR p75 Antibody (0.N.469): m-IgG1 BP-HRP Bundle | sc-541459 | 200 µg Ab; 20 µg BP | $361.00 |