Neuralized-2 Antibody (A-11): sc-398195

Neuralized-2 Antibody (A-11) is a mouse monoclonal IgM antibody that detects Neuralized-2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Neuralized-2 antibody (A-11) is available as the non-conjugated form. Neuralized-2, also known as NEURL2, OZZ, or Ozz-E3, is a 285 amino acid cytoplasmic protein that plays a crucial role in myofiber differentiation and maturation, processes essential for muscle development and repair. Neuralized-2 is predominantly expressed in skeletal and cardiac muscle, where Neuralized-2 localizes to the tips of differentiating myofibers, regulating the ubiquitination and degradation of β-catenin at the sarcolemma, a critical step in muscle cell signaling and function. Neuralized-2 (A-11) antibody is vital for maintaining proper muscle structure and function, ensuring timely degradation of β-catenin, which, if accumulated, can lead to aberrant signaling pathways and muscle pathologies. Neuralized-2 contains one SOCS box domain that facilitates interaction with Elongin B and Elongin C, as well as one neuralized homology repeat domain implicated in binding to ubiquitination substrates. The gene encoding Neuralized-2 is located on human chromosome 20, a region associated with various diseases, including Creutzfeldt-Jakob disease, amyotrophic lateral sclerosis, and Alagille syndrome, highlighting Neuralized-2′s importance in both normal physiology and disease states.

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Neuralized-2 Antibody (A-11) References:

1. Examination of the human prion protein-like gene doppel for genetic susceptibility to sporadic and variant Creutzfeldt-Jakob disease.  |  Mead, S., et al. 2000. Neurosci Lett. 290: 117-20. PMID: 10936691
2. Ozz-E3, a muscle-specific ubiquitin ligase, regulates beta-catenin degradation during myogenesis.  |  Nastasi, T., et al. 2004. Dev Cell. 6: 269-82. PMID: 14960280
3. A novel locus for late onset amyotrophic lateral sclerosis/motor neurone disease variant at 20q13.  |  Nishimura, AL., et al. 2004. J Med Genet. 41: 315-20. PMID: 15060112
4. Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1.  |  Song, R., et al. 2006. J Biol Chem. 281: 36391-400. PMID: 17003037
5. Alagille syndrome with deletion 20p12.2-p12.3 and hypoplastic left heart.  |  Robert, ML., et al. 2007. Clin Dysmorphol. 16: 241-6. PMID: 17786115
6. Candidate-gene testing for orphan limb-girdle muscular dystrophies.  |  Aurino, S., et al. 2008. Acta Myol. 27: 90-7. PMID: 19472918

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Neuralized-2 Antibody (A-11) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Neuralized-2 Antibody (A-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Neuralized-2 Antibody (A-11) Specifications

Alternate Product Name: Neuralized-2

Product Clone Name: A-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 7-20

Epitope Target: Neuralized-2

Epitope Species: human

Product Reactivity/Detection: Neuralized-2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Neuralized-2 Antibody (A-11): P: Blocking Peptide