Molecular structure of Meropenem, CAS Number: 96036-03-2
Meropenem (CAS 96036-03-2)
See product citations (4)
Alternate Names:
Meropenem aslo known as Meropenemum; Mesalazine; Mesalamine; Meropen; Merrem; Meropenem Sodium Carbonate
Application:
Meropenem is an antibiotic of the carbapenem subclass that has a high affinity for cell wall-synthesizing enzymes
CAS Number:
96036-03-2
Purity:
≥99%
Molecular Weight:
383.46
Molecular Formula:
C17H25N3O5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Meropenem is a beta-lactam antibiotic of the carbapenem subclass that may act to inhibit penicillinase-negative, -positive and methicillin-susceptible staphylococci. This compound demonstrates the ability to also affect strains of 11 species of streptococci. Mechanistic studies suggest that Meropenem′s antimicrobial activity is based on its high affinity for the majority of penicillin-binding proteins, which are cell wall-synthesizing enzymes. Meropenem is very effective because it resists inactivation by the majority of microbial LACTB (beta-lactamases) as well as kidney dehydropeptidase I. Experiments have shown Meropenem to have a low toxicity profile and, in contrast to similar compounds, no central nervous system toxicity.
Meropenem (CAS 96036-03-2) References
- Cellular and molecular aspects of drugs of the future: meropenem. | Cottagnoud, P. 2002. Cell Mol Life Sci. 59: 1928-33. PMID: 12530523
- Pharmacokinetic and pharmacodynamic properties of meropenem. | Nicolau, DP. 2008. Clin Infect Dis. 47 Suppl 1: S32-40. PMID: 18713048
- Activity of meropenem, against gram-positive bacteria. | Kayser, FH., et al. 1989. J Antimicrob Chemother. 24 Suppl A: 101-12. PMID: 2808202
- Meropenem as an antidote for intentional valproic acid overdose. | Thomas, C., et al. 2020. Am J Emerg Med. 38: 690.e1-690.e2. PMID: 31980292
- Clinical outcomes of continuous vs intermittent meropenem infusion for the treatment of sepsis: A systematic review and meta-analysis. | Chen, P., et al. 2020. Adv Clin Exp Med. 29: 993-1000. PMID: 32783408
- Meropenem use and therapeutic drug monitoring in clinical practice: a literature review. | Steffens, NA., et al. 2021. J Clin Pharm Ther. 46: 610-621. PMID: 33533509
- Oxygenator impact on meropenem/vaborbactam in extracorporeal membrane oxygenation circuits. | Cies, JJ., et al. 2022. Perfusion. 37: 729-737. PMID: 34034594
- Comparison between meropenem and ceftolozane/tazobactam: possible influence of CRRT. | Honore, PM., et al. 2022. Crit Care. 26: 15. PMID: 34996512
- Meropenem to Treat Valproic Acid Intoxication. | Smolders, EJ., et al. 2022. Ther Drug Monit. 44: 359-362. PMID: 35170557
- Interactions Between Meropenem and Renal Drug Transporters. | Dong, J., et al. 2022. Curr Drug Metab. 23: 423-431. PMID: 35490314
- Efficacy of Amikacin and Meropenem on Colistin-Induced Klebsiella pneumoniae Persisters. | Vatansever, C., et al. 2022. Microb Drug Resist. 28: 765-772. PMID: 35759379
- Meropenem Population Pharmacokinetics and Simulations in Plasma, Cerebrospinal Fluid, and Brain Tissue. | Alshaer, MH., et al. 2022. Antimicrob Agents Chemother. 66: e0043822. PMID: 35862739
- Meropenem plus Ceftaroline Is Active against Enterococcus faecalis in an In Vitro Pharmacodynamic Model Using Humanized Dosing Simulations. | Cusumano, JA., et al. 2022. Antimicrob Agents Chemother. 66: e0042622. PMID: 36154173
- [Clinical pharmacology and indications of meropenem in severe pediatric infection]. | Honorato, J., et al. 1997. Enferm Infecc Microbiol Clin. 15 Suppl 1: 38-44. PMID: 9410068
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Meropenem, 25 mg | sc-205746 | 25 mg | $98.00 | |||
Meropenem, 100 mg | sc-205746A | 100 mg | $275.00 | |||
Meropenem, 1 g | sc-205746B | 1 g | $357.00 |