Margatoxin (CAS 145808-47-5)
See product citations (2)
Alternate Names:
Margatoxin, Recombinant, E. coli
Application:
Margatoxin is a specific blocker of Kv1.3, Kv1.6 channels
CAS Number:
145808-47-5
Purity:
≥98%
Molecular Weight:
4178.96
Molecular Formula:
C178H286N52O50S7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Margatoxin, Recombinant is originally isolated from the scorpion Centruroides margaritatus, is a specific blocker of Kv1.3, Kv1.6 channels and a splice variant of the Drosophila Shaker channels. In Xenopus oocytes the toxin was less potent and inhibited expressed Kv1.3 channels with an apparent IC50 of ~1 nM. Margatoxin has been shown induce c-fos like protein and mRNA in rat organotypic dorsal striatal slices. But in human endothelial cells margatoxin inhibited VEGF-induced hyperpolarization, proliferation and nitric oxide production.
Margatoxin (CAS 145808-47-5) References
- Potassium channels in rat prostate epithelial cells. | Ouadid-Ahidouch, H., et al. 1999. FEBS Lett. 459: 15-21. PMID: 10508909
- Margatoxin and iberiotoxin, two selective potassium channel inhibitors, induce c-fos like protein and mRNA in rat organotypic dorsal striatal slices. | Saria, A., et al. 2000. Amino Acids. 19: 23-31. PMID: 11026470
- Margatoxin inhibits VEGF-induced hyperpolarization, proliferation and nitric oxide production of human endothelial cells. | Erdogan, A., et al. 2005. J Vasc Res. 42: 368-76. PMID: 16043967
- Recombinant expression of margatoxin and agitoxin-2 in Pichia pastoris: an efficient method for production of KV1.3 channel blockers. | Anangi, R., et al. 2012. PLoS One. 7: e52965. PMID: 23300835
- [125I]margatoxin, an extraordinarily high affinity ligand for voltage-gated potassium channels in mammalian brain. | Knaus, HG., et al. 1995. Biochemistry. 34: 13627-34. PMID: 7577952
- Chemical synthesis and structure-function studies of margatoxin, a potent inhibitor of voltage-dependent potassium channel in human T lymphocytes. | Bednarek, MA., et al. 1994. Biochem Biophys Res Commun. 198: 619-25. PMID: 8297371
- Comparative in vitro activity of nafcillin, oxacillin, and methicillin in combination with gentamicin and tobramycin against enterococci. | Watanakunakorn, C. and Glotzbecker, C. 1977. Antimicrob Agents Chemother. 11: 88-91. PMID: 836017
- Purification, characterization, and biosynthesis of margatoxin, a component of Centruroides margaritatus venom that selectively inhibits voltage-dependent potassium channels. | Garcia-Calvo, M., et al. 1993. J Biol Chem. 268: 18866-74. PMID: 8360176
- Margatoxin binds to a homomultimer of K(V)1.3 channels in Jurkat cells. Comparison with K(V)1.3 expressed in CHO cells. | Helms, LM., et al. 1997. Biochemistry. 36: 3737-44. PMID: 9132027
- Margatoxin increases dopamine release in rat striatum via voltage-gated K+ channels. | Saria, A., et al. 1998. Eur J Pharmacol. 343: 193-200. PMID: 9570467
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Margatoxin, 100 µg | sc-358754 | 100 µg | $200.00 | |||
Margatoxin, 500 µg | sc-358754A | 500 µg | $600.00 | |||
Margatoxin, 1 mg | sc-358754B | 1 mg | $900.00 | |||
Margatoxin, 5 mg | sc-358754C | 5 mg | $3100.00 | |||
Margatoxin, 10 mg | sc-358754D | 10 mg | $4500.00 |