MAG Antibody (E-1): sc-166921
- MAG Antibody (E-1) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 1-300 mapping near the N-terminus of MAG of human origin
- recommended for detection of MAG of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for MAG Antibody (E-1) for WB and IHC(P) applications. These reagents are now offered in bundles with MAG Antibody (E-1) (see ordering information below).
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MAG Antibody (E-1) is a mouse monoclonal IgG1 antibody that detects myelin-associated glycoprotein (MAG) in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). MAG is a crucial cell-surface adhesion protein in the nervous system, primarily located on the surface of myelinating glial cells, where MAG plays a vital role in linking these cells to neuronal axons. This interaction is essential for the maintenance of myelin integrity and the overall health of the nervous system. MAG on the cell surface not only facilitates the adhesion of glial cells to axons but also contributes to the inhibitory environment of myelin, which is important for regulating neuronal growth and preventing excessive axonal outgrowth. Understanding MAG localization and function is critical, as disruptions in MAG expression or function can lead to demyelinating diseases and neurodegenerative conditions. Anti-MAG antibody (E-1) is an invaluable tool for researchers studying the mechanisms of myelination and the pathophysiology of neurological disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MAG Antibody (E-1) References:
- Myelin-associated glycoprotein-mediated signaling in central nervous system pathophysiology. | Chen, Y., et al. 2006. Mol Neurobiol. 34: 81-91. PMID: 17220531
- Myelin-associated glycoprotein (MAG) protects neurons from acute toxicity using a ganglioside-dependent mechanism. | Mehta, NR., et al. 2010. ACS Chem Neurosci. 1: 215-222. PMID: 20436925
- Myelin-associated glycoprotein gene and brain morphometry in schizophrenia. | Felsky, D., et al. 2012. Front Psychiatry. 3: 40. PMID: 22563322
- Myelin-associated glycoprotein-related neuropathy associated with psoriasis: a case report. | Murata, KY., et al. 2013. J Med Case Rep. 7: 4. PMID: 23286283
- Myelin-associated glycoprotein and other proteins in Trembler mice. | Inuzuka, T., et al. 1985. J Neurochem. 44: 793-7. PMID: 2579197
- Nerve Hypertrophy and Altered Diffusion in Anti-Myelin-Associated Glycoprotein Neuropathy Detected by Brachial Plexus Magnetic Resonance Neurography. | Koide, K., et al. 2022. Eur Neurol. 85: 95-103. PMID: 34583351
- Antibody cross-reactivity between casein and myelin-associated glycoprotein results in central nervous system demyelination. | Chunder, R., et al. 2022. Proc Natl Acad Sci U S A. 119: e2117034119. PMID: 35235454
- Myelin-associated glycoprotein is the antigen for a monoclonal IgM in polyneuropathy. | Braun, PE., et al. 1982. J Neurochem. 39: 1261-5. PMID: 6181197
- Myelin basic protein and myelin-associated glycoprotein in chronic, relapsing experimental allergic encephalomyelitis. | Sternberger, NH., et al. 1984. J Neuroimmunol. 6: 217-29. PMID: 6203931
- Myelin-associated glycoprotein inhibits neurite/axon growth and causes growth cone collapse. | Li, M., et al. 1996. J Neurosci Res. 46: 404-14. PMID: 8950700
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MAG Antibody (E-1) | sc-166921 | 200 µg/ml | $322.00 | |||
MAG Antibody (E-1): m-IgG Fc BP-HRP Bundle | sc-540175 | 200 µg Ab; 10 µg BP | $361.00 | |||
MAG Antibody (E-1): m-IgG1 BP-HRP Bundle | sc-541949 | 200 µg Ab; 20 µg BP | $361.00 |