Lyn Antibody (42): sc-136259
- Lyn Antibody (42) is a mouse monoclonal IgG1 provided at 50 µg/0.5 ml
- raised against amino acids 1-138 of Lyn of human origin
- recommended for detection of Lyn of mouse, rat, human and canine origin by WB, IP and IF
- See Lyn (H-6): sc-7274 for Lyn antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Lyn Antibody (42). This work is in progress.
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Lyn Antibody (42) is a mouse monoclonal IgG1 antibody that detects Lyn in mouse, rat, human, and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Lyn is a member of the Src family of non-receptor tyrosine kinases, which play a crucial role in various cellular processes, including the regulation of immune responses and hematopoiesis. Lyn is predominantly expressed in hematopoietic tissues, where Lyn is essential for normal immunoglobulin production and the modulation of immune cell signaling. Lyn activity is tightly regulated, as Lyn is typically maintained in an inactive state and can be activated in response to specific stimuli, such as antigen receptor engagement. This regulation is vital for preventing aberrant signaling that could lead to autoimmune diseases or malignancies. The Lyn gene is located on chromosome 8q12 and encodes a 505 amino acid protein, which features a unique structure that includes an amino-terminal membrane anchor, an SH3 domain, and an SH2 domain, all of which are critical for function and interaction with other signaling molecules. Anti-Lyn antibody (42) provides a powerful tool for researchers studying the intricate signaling pathways involving Lyn and its role in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Lyn Antibody (42) References:
- Multiple roles of Lyn kinase in myeloid cell signaling and function. | Scapini, P., et al. 2009. Immunol Rev. 228: 23-40. PMID: 19290919
- Astaxanthin Improves Human Sperm Capacitation by Inducing Lyn Displacement and Activation. | Andrisani, A., et al. 2015. Mar Drugs. 13: 5533-51. PMID: 26308013
- Role of Membrane Cholesterol Levels in Activation of Lyn upon Cell Detachment. | Morinaga, T., et al. 2018. Int J Mol Sci. 19: PMID: 29921831
- Sorting Nexin 10 Mediates Metabolic Reprogramming of Macrophages in Atherosclerosis Through the Lyn-Dependent TFEB Signaling Pathway. | You, Y., et al. 2020. Circ Res. 127: 534-549. PMID: 32316875
- Lyn kinase regulates egress of flaviviruses in autophagosome-derived organelles. | Li, MY., et al. 2020. Nat Commun. 11: 5189. PMID: 33060596
- Therapeutic targeting of Lyn kinase to treat chorea-acanthocytosis. | Peikert, K., et al. 2021. Acta Neuropathol Commun. 9: 81. PMID: 33941276
- Immune Characteristics of LYN in Tumor Microenvironment of Gliomas. | Jiang, C., et al. 2021. Front Cell Dev Biol. 9: 760929. PMID: 35186945
- Lyn Phosphorylates and Controls ROR1 Surface Dynamics During Chemotaxis of CLL Cells. | Dave, Z., et al. 2022. Front Cell Dev Biol. 10: 838871. PMID: 35295854
- A Special Thanks to Lyn Reynolds, Director of the ADA Editorial Office, as She Embarks on Her Retirement. | Riddle, MC., et al. 2022. Clin Diabetes. 40: 399-400. PMID: 36385978
- Fyn, Blk, and Lyn kinase inhibitors: A mini-review on medicinal attributes, research progress, and future insights. | Kohal, R., et al. 2024. Bioorg Med Chem Lett. 102: 129674. PMID: 38408513
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Lyn Antibody (42) | sc-136259 | 50 µg/0.5 ml | $322.00 |