Lyn Antibody (2H8D7): sc-101849
- Lyn Antibody (2H8D7) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against purified truncated recombinant Lyn of human origin
- recommended for detection of Lyn of human origin by WB, IP and ELISA
- See Lyn (H-6): sc-7274 for Lyn antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for Lyn Antibody (2H8D7) for WB applications. This reagent is now offered in a bundle with Lyn Antibody (2H8D7) (see ordering information below).
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Lyn Antibody (2H8D7) is a mouse monoclonal IgG1 antibody that detects Lyn in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Lyn is a member of the Src family of non-receptor tyrosine kinases, which play a crucial role in various cellular processes, including the regulation of immune responses. Lyn is predominantly expressed in hematopoietic tissues, where Lyn is essential for normal immunoglobulin production and the modulation of immune cell signaling. The structure of Lyn includes a unique amino-terminal membrane anchor, followed by SH3 and SH2 domains that facilitate interaction with other proteins and activation during critical cellular events. Understanding Lyn structure is vital, as alterations in Lyn function can lead to dysregulation in immune responses and contribute to diseases such as leukemia and lymphoma. Anti-Lyn antibody (2H8D7) is an invaluable tool for studying these processes and advancing our knowledge of immune system regulation.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Lyn Antibody (2H8D7) References:
- Lyn/CD22/SHP-1 and their importance in autoimmunity. | Blasioli, J. and Goodnow, CC. 2002. Curr Dir Autoimmun. 5: 151-60. PMID: 11826756
- Lyn, Lupus, and (B) Lymphocytes, a Lesson on the Critical Balance of Kinase Signaling in Immunity. | Brodie, EJ., et al. 2018. Front Immunol. 9: 401. PMID: 29545808
- The role of the tyrosine kinase Lyn in allergy and cancer. | Sun, Y., et al. 2021. Mol Immunol. 131: 121-126. PMID: 33419562
- The Src-family Kinase Lyn in Immunoreceptor Signaling. | Brian, BF. and Freedman, TS. 2021. Endocrinology. 162: PMID: 34320188
- Fumarate suppresses B-cell activation and function through direct inactivation of LYN. | Cheng, J., et al. 2022. Nat Chem Biol. 18: 954-962. PMID: 35710616
- Lyn attenuates sepsis-associated acute kidney injury by inhibition of phospho-STAT3 and apoptosis. | Li, N., et al. 2023. Biochem Pharmacol. 211: 115523. PMID: 37003346
- Lyn-mediated glycolysis enhancement of microglia contributes to neuropathic pain through facilitating IRF5 nuclear translocation in spinal dorsal horn. | Kong, E., et al. 2023. J Cell Mol Med. 27: 1664-1681. PMID: 37132040
- Aspartoacylase suppresses prostate cancer progression by blocking LYN activation. | Weng, H., et al. 2023. Mil Med Res. 10: 25. PMID: 37271807
- CD36/Lyn kinase interactions within macrophages promotes pulmonary fibrosis in response to oxidized phospholipid. | Kwak, D., et al. 2023. Respir Res. 24: 314. PMID: 38098035
- Lyn, a src-like tyrosine kinase. | Hibbs, ML. and Dunn, AR. 1997. Int J Biochem Cell Biol. 29: 397-400. PMID: 9202419
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Lyn Antibody (2H8D7) | sc-101849 | 200 µg/ml | $322.00 | |||
Lyn Antibody (2H8D7): m-IgG Fc BP-HRP Bundle | sc-539793 | 200 µg Ab; 10 µg BP | $361.00 |