LY-294,002 hydrochloride CAS: 934389-88-5
MF: C19H17NO3•HCl
MW: 343.81
A highly selective inhibitor of PI 3-kinase.

LY-294,002 hydrochloride (CAS 934389-88-5)

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Nomi alternativi: 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one hydrochloride
Applicazione: LY-294,002 hydrochloride is a highly selective inhibitor of PI 3-kinase
Numero CAS: 934389-88-5
Peso molecolare: 343.81
Formula molecolare: C19H17NO3•HCl
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).

LY-294,002 hydrochloride is a highly selective inhibitor of PI 3-kinase (IC50 values are 0.31, 0.73, 1.06 and 6.60 μM for PI3Kβ, PI3Kα, PI3Kδ and PI3Kγ respectively). LY-294,002 hydrochloride induces apoptosis in many cell types by blocking the PI 3-kinase/Akt anti-apoptotic pathway. LY-294,002 hydrochloride is an inhibitor of Pim-1.


Referenze

1. Vlahos, C.J., et al., A specific inhibitor of phosphatidylinositol 3-kinase 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J. Biol. Chem. 269, 5241, (1994) 2. Brunn, G.J., et al., Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002. EMBO J. 15, 5256-5267, (1996) 3. Vlahos, C.J., et al., Investigation of neutrophil signal transduction using a specific inhibitor of phosphatidylinositol 3-kinase. J. Immunol. 154, 2413-2422, (1995) 4. Chasserot-Golaz et al (1998) Possible involvement of phosphatidyl-3-kinase in regulated exocytosis: studies in chromaffin cells with inhibitor LY 294002. J.Neurochem. 70 2347. 5. Ferrandi et al (2007) Phosphoinositide 3-kinase g inhibition plays a crucial role in early steps of inflammation by blocking neutrophil recruitment. J.Pharmacol. Exp.Ther. 322 923.

Aspetto :
Crystalline
Stato fisico :
Solid
Solubilità :
Soluble in DMSO (25 mM) and Ethanol (5 mM)
CONSERVAZIONE :
Store at room temperature
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
PubChem CID :
11957589
SMILES :
C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC=C4.Cl

Download SDS (MSDS)

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LY-294,002 hydrochloride (CAS 934389-88-5)  Citazioni prodotti

Vedi quanti altri hanno usato LY-294,002 hydrochloride (CAS 934389-88-5). Clicca sulla voce per laccesso a PubMed .

Ciatazioni 1 a1 di 1 totali

PMID: # 27739443  Lo Cicero, A. et al. 2016. Sci Rep. 6: 34798.

Ciatazioni 1 a1 di 1 totali
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