LRP130 Antibody (E-12): sc-376657
- LRP130 Antibody (E-12) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 1007-1306 mapping at the C-terminus of LRP130 of mouse origin
- recommended for detection of LRP130 of mouse, rat and human origin by WB, IP, IF and ELISA
- TransCruz reagent for ChIP application (sc-376657 X, 200 µg/0.1 ml)
- See LRP130 (F-7): sc-166178 for LRP130 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for LRP130 Antibody (E-12) for WB applications. These reagents are now offered in bundles with LRP130 Antibody (E-12) (see ordering information below).
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LRP130 Antibody (E-12) is a mouse monoclonal IgG1 antibody that detects LRP130 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LRP130, a leucine-rich protein, plays a crucial role as a cytoplasmic mRNA-binding protein involved in the processing of mitochondrial DNA transcripts, which is essential for maintaining mitochondrial function and energy production within cells. The proper functioning of LRP130 is vital, as defects in the LRPPRC gene that encodes this protein are linked to the French-Canadian type of Leigh syndrome, a severe neurological disorder characterized by lesions in the subcortical region of the brain. Additionally, LRP130 interacts with the low-affinity receptor for leukemia inhibitory factor, initiating an intracellular signaling cascade that can influence various cellular processes. Anti-LRP130 antibody (E-12) serves as an invaluable tool for researchers studying mitochondrial function and related diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
LRP130 Antibody (E-12) References:
- LRPPRC is a mitochondrial matrix protein that is conserved in metazoans. | Sterky, FH., et al. 2010. Biochem Biophys Res Commun. 398: 759-64. PMID: 20633537
- LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs. | Ruzzenente, B., et al. 2012. EMBO J. 31: 443-56. PMID: 22045337
- LRPPRC sustains Yap-P27-mediated cell ploidy and P62-HDAC6-mediated autophagy maturation and suppresses genome instability and hepatocellular carcinomas. | Li, W., et al. 2020. Oncogene. 39: 3879-3892. PMID: 32203162
- LRPPRC regulates metastasis and glycolysis by modulating autophagy and the ROS/HIF1-α pathway in retinoblastoma. | Song, K., et al. 2021. Mol Ther Oncolytics. 22: 582-591. PMID: 34589577
- Mitochondrial-Associated Protein LRPPRC is Related With Poor Prognosis Potentially and Exerts as an Oncogene Via Maintaining Mitochondrial Function in Pancreatic Cancer. | Wang, L., et al. 2021. Front Genet. 12: 817672. PMID: 35237297
- LRPPRC inhibits autophagy and promotes foam cell formation in atherosclerosis. | Xu, Z., et al. 2022. FEBS J. 289: 7545-7560. PMID: 35792704
- GREM1, LRPPRC and SLC39A4 as potential biomarkers of intervertebral disc degeneration: a bioinformatics analysis based on multiple microarray and single-cell sequencing data. | Zhang, Z., et al. 2023. BMC Musculoskelet Disord. 24: 729. PMID: 37700277
- An LRPPRC-HAPSTR1-PSMD14 interaction regulates tumor progression in ovarian cancer. | Li, D. and Wang, M. 2024. Aging (Albany NY). 16: 6773-6795. PMID: 38643468
- Structural basis of LRPPRC-SLIRP-dependent translation by the mitoribosome. | Singh, V., et al. 2024. Nat Struct Mol Biol.. PMID: 39134711
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LRP130 Antibody (E-12) | sc-376657 | 200 µg/ml | $322.00 | |||
LRP130 Antibody (E-12): m-IgG Fc BP-HRP Bundle | sc-537994 | 200 µg Ab; 10 µg BP | $361.00 | |||
LRP130 Antibody (E-12): m-IgGκ BP-HRP Bundle | sc-535499 | 200 µg Ab; 40 µg BP | $361.00 | |||
LRP130 Antibody (E-12): m-IgG1 BP-HRP Bundle | sc-545479 | 200 µg Ab; 20 µg BP | $361.00 | |||
LRP130 Antibody (E-12) X | sc-376657 X | 200 µg/0.1 ml | $322.00 |