LRP1 Antibody (8B8): sc-57352
- LRP1 Antibody (8B8) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 100 µg/ml
- raised against light chain LRP1
- recommended for detection of light chain of LRP1 of mouse, rat and human origin by WB, IF, IHC(P) and FCM; also reactive with additional species, including rabbit
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for LRP1 Antibody (8B8). This work is in progress.
LRP1 Antibody (8B8) is a mouse monoclonal IgG1 kappa light chain antibody designed to detect the Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1), also known as the α2-Macroglobulin Receptor (α2MR). LRP1 is a multifunctional endocytic receptor that plays a pivotal role in the internalization of a wide array of ligands, including α2-Macroglobulin and apolipoprotein E (apoE), which are essential for lipid metabolism, protease clearance, and cellular signaling pathways. Structurally, LRP1 is characterized by its extensive extracellular domain composed of multiple clusters of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats, and an O-linked sugar domain, which are critical for ligand binding and receptor function. Post-translational modifications of LRP1, such as glycosylation and proteolytic cleavage, are crucial for proper folding, trafficking to the cell surface, and the formation of functional membrane and extracellular subunits. These modifications ensure that LRP1 maintains structural integrity and binding affinity, thereby facilitating its role in maintaining cellular homeostasis and mediating endocytosis. LRP1 (8B8) antibody is raised against the light chain of full-length native human LRP1 across multiple species, including mouse, rat, human, and rabbit. LRP1 monoclonal antibody (8B8) is recommended for use in various applications such as western blotting (WB), immunofluorescence (IF), immunohistochemistry (IHC), and flow cytometry (FCM), making it a versatile research tool.
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LRP1 Antibody (8B8) References:
- Apolipoprotein E and renal disease. | Liberopoulos, E., et al. 2004. Am J Kidney Dis. 43: 223-33. PMID: 14750087
- Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease. | Holtzman, DM., et al. 2012. Cold Spring Harb Perspect Med. 2: a006312. PMID: 22393530
- Apolipoprotein E Isoforms and AMD. | Toops, KA., et al. 2016. Adv Exp Med Biol. 854: 3-9. PMID: 26427386
- Apolipoprotein E: the resilience gene. | James, LM., et al. 2017. Exp Brain Res. 235: 1853-1859. PMID: 28299413
- LDL receptor-related protein 1 (LRP1), a novel target for opening the blood-labyrinth barrier (BLB). | Shi, X., et al. 2022. Signal Transduct Target Ther. 7: 175. PMID: 35680846
- Apolipoprotein E regulates chromatin stability and senescence. | Wang, L. and Dou, Z. 2022. Nat Aging. 2: 282-284. PMID: 37117742
- Loss of LRP1 in Adult Neural Stem Cells Impairs Migration to Ischemic Lesions. | Dietert, K., et al. 2023. Stem Cells. 41: 570-577. PMID: 37186298
- Apolipoprotein E intersects with amyloid-β within neurons. | Konings, SC., et al. 2023. Life Sci Alliance. 6: PMID: 37290814
- LRP1 Repression by SNAIL Results in ECM Remodeling in Genetic Risk for Vascular Diseases. | Liu, L., et al. 2024. Circ Res.. PMID: 39355906
- Apolipoprotein E and the apolipoprotein E-deficient mouse. | Plump, AS. and Breslow, JL. 1995. Annu Rev Nutr. 15: 495-518. PMID: 8527231
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LRP1 Antibody (8B8) | sc-57352 | 100 µg/ml | $322.00 |