LRP1 Antibody (5A6): sc-57351

LRP1 Antibody (5A6) is a mouse monoclonal IgG2b antibody designed to detect Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1), also known as α2-Macroglobulin Receptor (α2MR). LRP1 is a large, multifunctional endocytic receptor characterized by its complex structure, which includes clusters of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats, and an O-linked sugar domain. This intricate architecture enables LRP1 to interact with a diverse array of ligands, facilitating essential processes such as lipid metabolism, protease clearance, and cellular signaling. The structural integrity of LRP1 is crucial for maintaining cellular homeostasis and enabling the uptake of over fifteen different ligands, including α2-Macroglobulin and apolipoprotein E (apoE). LRP1 is predominantly expressed on the cell surface in key tissues like the brain, liver, and lungs, highlighting its importance in neurological health, metabolic regulation, and respiratory function. Anti-LRP1 antibody (5A6) targets the full-length native human LRP1, specifically recognizing the 85 kDa cleaved fragment of the protein across multiple species, including mouse, rat, and human for applications such as western blotting (WB), immunofluorescence (IF), immunohistochemistry (IHC), and flow cytometry (FCM). By enabling precise analysis of LRP1′s structural domains, LRP1 (5A6) antibody supports advanced studies into its critical roles in physiological processes and involvement in pathological conditions like Alzheimer′s disease, where the LRP1 gene is located at a significant locus on chromosome 12.

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LRP1 Antibody (5A6) References:

1. Molecular biology of apolipoprotein E.  |  Strittmatter, WJ. and Bova Hill, C. 2002. Curr Opin Lipidol. 13: 119-23. PMID: 11891413
2. Apolipoprotein E polymorphism and atherosclerosis.  |  Kolovou, G., et al. 2003. Angiology. 54: 59-71. PMID: 12593497
3. Apolipoprotein E isoforms and lipoprotein metabolism.  |  Phillips, MC. 2014. IUBMB Life. 66: 616-23. PMID: 25328986
4. Role of apolipoprotein E in neurodegenerative diseases.  |  Giau, VV., et al. 2015. Neuropsychiatr Dis Treat. 11: 1723-37. PMID: 26213471
5. Multiple system atrophy and apolipoprotein E.  |  Ogaki, K., et al. 2018. Mov Disord. 33: 647-650. PMID: 29442376
6. Aging and Apolipoprotein E in HIV Infection.  |  Geffin, R. and McCarthy, M. 2018. J Neurovirol. 24: 529-548. PMID: 29987582
7. Lrp1 Regulation of Pulmonary Function. Follow-Up of Human GWAS in Mice.  |  Nichols, CE., et al. 2021. Am J Respir Cell Mol Biol. 64: 368-378. PMID: 33290178
8. Apolipoprotein E potently inhibits ferroptosis by blocking ferritinophagy.  |  Belaidi, AA., et al. 2024. Mol Psychiatry. 29: 211-220. PMID: 35484240
9. Low-density lipoprotein receptor-related protein 1 (LRP1) as an auxiliary host factor for RNA viruses.  |  Devignot, S., et al. 2023. Life Sci Alliance. 6: PMID: 37072184
10. LRP1 in GABAergic neurons is a key link between obesity and memory function.  |  da Cruz Rodrigues, KC., et al. 2024. Mol Metab. 84: 101941. PMID: 38636794

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LRP1 Antibody (5A6) has 12 citations in a variety of scientific publications.

Primary antibodies like Anti-LRP1 Antibody (5A6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LRP1 Antibody (5A6) Specifications

Alternate Product Name: LRP1

Product Clone Name: 5A6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b

Amino Acids:

Epitope Target: LRP1

Epitope Species: human

Product Reactivity/Detection: 85 kDa cleaved fragment of Low Density LRP1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB (non-reducing), IF, IHC(P), FCM

Vialing Information: Each vial contains 100 µg IgG_2b in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 12 citations in various scientific publications

Available Conjugates/Forms for LRP1 Antibody (5A6): N/A

The preferred LRP1 antibody is LRP1 Antibody (8G1): sc-57353.