LIS1 Antibody (G-3): sc-17817
- LIS1 Antibody (G-3) is a mouse monoclonal IgG2b κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 1-300 of LIS1 of human origin
- recommended for detection of LIS1 of mouse, rat and human origin by WB, IP, IF and IHC(P)
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for LIS1 Antibody (G-3) for WB and IHC(P) applications. These reagents are now offered in bundles with LIS1 Antibody (G-3) (see ordering information below).
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LIS1 Antibody (G-3) is a mouse monoclonal IgG2b light chain antibody that detects lissencephaly-1 protein (LIS1) of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). LIS1 plays a critical role in neuronal migration during brain development, and proper function is essential for the formation of a normal cerebral cortex. Mutations in LIS1 can lead to lissencephaly, a condition characterized by a smooth brain surface and severe cognitive impairments. LIS1 is primarily located in the cytoplasm and interacts with microtubules, which are vital for the transport of cellular components and maintenance of cell shape. This interaction is crucial for the migration of neurons during embryonic development, helping guide them to appropriate locations in the developing brain. anti-LIS1 antibody (G-3) is an invaluable tool for researchers studying the mechanisms of neuronal migration and underlying causes of lissencephaly, providing insights that could lead to potential therapeutic strategies for related neurological disorders.
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LIS1 Antibody (G-3) References:
- LIS1 and spindle orientation in neuroepithelial cells. | Schwamborn, JC. and Knoblich, JA. 2008. Cell Stem Cell. 2: 193-4. PMID: 18371441
- LIS1 functions in normal development and disease. | Reiner, O. and Sapir, T. 2013. Curr Opin Neurobiol. 23: 951-6. PMID: 23973156
- Lis1 mutation prevents basal radial glia-like cell production in the mouse. | Penisson, M., et al. 2022. Hum Mol Genet. 31: 942-957. PMID: 34635911
- Structural basis for cytoplasmic dynein-1 regulation by Lis1. | Gillies, JP., et al. 2022. Elife. 11: PMID: 34994688
- LIS1 and NDEL1 Regulate Axonal Trafficking of Mitochondria in Mature Neurons. | Pandey, JP., et al. 2022. Front Mol Neurosci. 15: 841047. PMID: 35465088
- Lis1-dynein drives corona compaction and limits erroneous microtubule attachment at kinetochores. | Mitevska, O., et al. 2023. J Cell Sci. 136: PMID: 36274587
- LIS1 RNA-binding orchestrates the mechanosensitive properties of embryonic stem cells in AGO2-dependent and independent ways. | Kshirsagar, A., et al. 2023. Nat Commun. 14: 3293. PMID: 37280197
- Lis1 relieves cytoplasmic dynein-1 autoinhibition by acting as a molecular wedge. | Karasmanis, EP., et al. 2023. Nat Struct Mol Biol. 30: 1357-1364. PMID: 37620585
- Lis1 slows force-induced detachment of cytoplasmic dynein from microtubules. | Kusakci, E., et al. 2024. Nat Chem Biol. 20: 521-529. PMID: 37919547
- Molecular mechanism of dynein-dynactin complex assembly by LIS1. | Singh, K., et al. 2024. Science. 383: eadk8544. PMID: 38547289
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LIS1 Antibody (G-3) | sc-17817 | 200 µg/ml | $322.00 | |||
LIS1 Antibody (G-3): m-IgGκ BP-HRP Bundle | sc-533744 | 200 µg Ab; 40 µg BP | $361.00 | |||
LIS1 Antibody (G-3): m-IgG2b BP-HRP Bundle | sc-549237 | 200 µg Ab; 10 µg BP | $361.00 |