IL-4Rα Antibody (D-2): sc-137257
- IL-4Rα Antibody (D-2) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 511-810 of IL-4Ra of mouse origin
- recommended for detection of IL-4Rα of mouse origin by WB, IP, IF and ELISA
- See IL-4Rα (H-4): sc-28361 for IL-4Rα antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for IL-4Rα Antibody (D-2) for WB applications. This reagent is now offered in a bundle with IL-4Rα Antibody (D-2) (see ordering information below).
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IL-4Rα Antibody (D-2) is a mouse monoclonal IgG1 antibody that detects IL-4Rα in mouse samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IL-4Rα, or interleukin-4 receptor alpha, plays a crucial role in the immune response by serving as a high-affinity receptor for interleukin-4, a key cytokine involved in T helper cell differentiation. IL-4Rα expression on immune cell surfaces is essential for mediating IL-4 effects, which include promoting T cell proliferation and enhancing immunoglobulin E production, a critical component in allergic responses. IL-4Rα interaction with its ligand initiates signaling pathways leading to T cell activation and influences the balance between different T helper cell subsets, impacting overall immune function. IL-4Rα forms a heterodimer with the common gamma chain (γc), which is shared among several cytokine receptors, further underscoring its importance in cytokine signaling and immune regulation. Anti-IL-4Rα antibody (D-2) serves as an invaluable tool for researchers studying immune responses and cytokine roles in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
IL-4Rα Antibody (D-2) References:
- Local amplifiers of IL-4Rα-mediated macrophage activation promote repair in lung and liver. | Minutti, CM., et al. 2017. Science. 356: 1076-1080. PMID: 28495878
- Murine IL-4Δ2 splice variant down-regulates IL-4 activities independently of IL-4Rα binding and STAT-6 phosphorylation. | Diogo, GR., et al. 2017. Cytokine. 99: 154-162. PMID: 28917204
- Association study on IL-4, IL-4Rα and IL-13 genetic polymorphisms in Swedish patients with colorectal cancer. | Shamoun, L., et al. 2018. Clin Chim Acta. 487: 101-106. PMID: 30227113
- Characterization of cryptic allosteric site at IL-4Rα: New paradigm towards IL-4/IL-4R inhibition. | Naz, S., et al. 2019. Int J Biol Macromol. 123: 239-245. PMID: 30391589
- IL-4Rα signalling in B cells and T cells play differential roles in acute and chronic atopic dermatitis. | Scibiorek, M., et al. 2023. Sci Rep. 13: 144. PMID: 36599893
- The IL-4Rα Q576R polymorphism is associated with increased severity of atopic dermatitis and exaggerates allergic skin inflammation in mice. | Yang, B., et al. 2023. J Allergy Clin Immunol. 151: 1296-1306.e7. PMID: 36690254
- Preclinical immunological characterization of rademikibart (CBP-201), a next-generation human monoclonal antibody targeting IL-4Rα, for the treatment of Th2 inflammatory diseases. | Zhang, L., et al. 2023. Sci Rep. 13: 12411. PMID: 37524768
- Diterpenoid DGT alleviates atopic dermatitis-like responses in vitro and in vivo via targeting IL-4Rα. | Gao, J., et al. 2024. Biomed Pharmacother. 179: 117321. PMID: 39191027
- Stapokibart (CM310) targets IL-4Rα for the treatment of type 2 inflammation. | Liu, W., et al. 2024. iScience. 27: 110721. PMID: 39262798
- The IL-4-IL-4Rα axis modulates olfactory neuroimmune signaling to induce loss of smell. | Hara, Y., et al. 2024. Allergy.. PMID: 39418114
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IL-4Rα Antibody (D-2) | sc-137257 | 200 µg/ml | $322.00 | |||
IL-4Rα Antibody (D-2): m-IgG Fc BP-HRP Bundle | sc-539972 | 200 µg Ab; 10 µg BP | $361.00 |