IGF-1 Receptor β/IGF1R Antibody (T8C8): sc-81764

IGF-IRβ Antibody (T8C8) is a mouse monoclonal IgG2a kappa light chain antibody raised against a recombinant protein corresponding to amino acids 1101-1367 of human IGF-IR, also known as insulin-like growth factor 1 receptor. IGF-IR (T8C8) antibody is validated for applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP), with species reactivity in humans. IGF-IR is a receptor tyrosine kinase located on the plasma membrane, where IGF-IR serves as a critical mediator of insulin-like growth factor I (IGF-I) signaling. This membrane localization is essential for ligand binding and the initiation of downstream signaling pathways, such as the Ras-ERK and PI3K-AKT cascades, which regulate cell proliferation, differentiation, and survival. Composed of α and β subunits, IGF-IR is encoded by the IGF-IR gene on chromosome 15q26.3, with the β subunit containing the intracellular tyrosine kinase domain responsible for propagating signals. The precise membrane localization of IGF-IR enables direct modulation of cellular responses to growth signals, inhibition of apoptosis, and contribution to tissue development and repair. Dysregulation of IGF-IR is associated with various pathological conditions, including cancer, where IGF-IR plays a role in promoting tumor growth and survival. Anti-IGF-IR antibody (T8C8) is a valuable resource for studying the localization and functional roles of IGF-IR in cellular signaling and disease.

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IGF-1 Receptor β/IGF1R Antibody (T8C8) References:

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3. Insulin-like growth factor 1 receptor regulates hypothermia during calorie restriction.  |  Cintron-Colon, R., et al. 2017. Proc Natl Acad Sci U S A. 114: 9731-9736. PMID: 28827363
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6. Insulin-Like Growth Factor-1 Receptor Targeted Fluorescent Imaging for Gallbladder Cancer in Orthotopic Mouse Models.  |  Choi, JH. and Park, JY. 2022. Gut Liver. 16: 606-612. PMID: 34462395
7. Phase I trial of Ganitumab plus Dasatinib to Cotarget the Insulin-Like Growth Factor 1 Receptor and Src Family Kinase YES in Rhabdomyosarcoma.  |  Akshintala, S., et al. 2023. Clin Cancer Res. 29: 3329-3339. PMID: 37398992
8. Insulin-like growth factor-1 receptor crosstalk with integrins, cadherins, and the tumor microenvironment: sticking points in understanding IGF1R function in cancer.  |  Galifi, CA. and Wood, TL. 2023. Endocr Relat Cancer. 30: PMID: 37490874
9. Blocking insulin-like growth factor 1 receptor signaling pathway inhibits neuromuscular junction regeneration after botulinum toxin-A treatment.  |  Ishihara, H., et al. 2023. Cell Death Dis. 14: 609. PMID: 37717026
10. Role of Insulin-like Growth Factor-1 Receptor in Tobacco Smoking-Associated Lung Cancer Development.  |  Shahid, A., et al. 2024. Biomedicines. 12: PMID: 38540176

The preferred IGF-1 Receptor β/IGF1R antibody is IGF-1 Receptor β/IGF1R Antibody (F-1): sc-390130.