IGF-1 Receptor α/IGF1R Antibody (26-3): sc-80987

IGF-IRα Antibody (26-3) is a mouse monoclonal IgG1 antibody that detects insulin-like growth factor-I receptor (IGF-IR) in human samples through immunoprecipitation (IP). IGF-IR plays a crucial role in cellular signaling pathways that regulate growth and survival, making IGF-IR (26-3) antibody a significant tool in cancer research and therapeutic development. This receptor tyrosine kinase resides on the cell membrane, where IGF-IR acts as a transducer of growth signals initiated by insulin-like growth factor-I (IGF-I). IGF-I binding to IGF-IR triggers a cascade of intracellular events, including Ras and ERK pathway activation, which drive cell proliferation and differentiation. IGF-IR′s membrane location enables rapid signal transduction and interaction with downstream signaling molecules, such as insulin receptor substrates (IRS), which further propagate growth signals. The human IGF-IR gene, located on chromosome 15q26.3, encodes a precursor protein that forms α and β subunits essential for functional activity. Anti-IGF-IR antibody (26-3) enables researchers to study IGF-IR signaling dynamics and implications in various biological processes and diseases.

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IGF-1 Receptor α/IGF1R Antibody (26-3) References:

1. Insulin-like growth factors I and II induce cell death in Wilms's tumour cells.  |  Granérus, M., et al. 2001. Mol Pathol. 54: 30-5. PMID: 11212886
2. Resistance to different antiestrogens is caused by different multi-factorial changes and is associated with reduced expression of IGF receptor Ialpha.  |  Brockdorff, BL., et al. 2003. Endocr Relat Cancer. 10: 579-90. PMID: 14713268
3. A novel selective progesterone receptor modulator asoprisnil (J867) down-regulates the expression of EGF, IGF-I, TGFbeta3 and their receptors in cultured uterine leiomyoma cells.  |  Wang, J., et al. 2006. Hum Reprod. 21: 1869-77. PMID: 16613890
4. Effects of leptin on human breast cancer cell lines in relationship to estrogen receptor and HER2 status.  |  Ray, A., et al. 2007. Int J Oncol. 30: 1499-509. PMID: 17487372
5. Growth inhibition of insulin-like growth factor I receptor monoclonal antibody to human colorectal cancer cells.  |  Zhang, Y. and Zhang, Y. 2008. Cancer Invest. 26: 230-6. PMID: 18317963
6. Serum insulin-like growth factor-I and mammary tumor development in ad libitum-fed, chronic calorie-restricted, and intermittent calorie-restricted MMTV-TGF-alpha mice.  |  Rogozina, OP., et al. 2009. Cancer Prev Res (Phila). 2: 712-9. PMID: 19654106
7. Inhibition of hepatocellular carcinoma cell growth by an anti-insulin-like growth factor-I receptor monoclonal antibody.  |  Yue, L., et al. 2012. Oncol Rep. 28: 1453-60. PMID: 22895605
8. Prolactin protects cardiomyocytes against intermittent hypoxia-induced cell damage by the modulation of signaling pathways related to cardiac hypertrophy and proliferation.  |  Hsieh, DJ., et al. 2015. Int J Cardiol. 181: 255-66. PMID: 25531577
9. Expression of Cell Surface Receptors on Human Glioblastoma Xenograft Model in NOD/SCID Mouse.  |  Oh, KS., et al. 2002. Cancer Res Treat. 34: 52-7. PMID: 26680843
10. Regulation of IGF-I by IGFBP3 and IGFBP5 during odontoblast differentiation in mice.  |  Aizawa, C., et al. 2019. J Oral Biosci. 61: 157-162. PMID: 31400542

The preferred IGF-1 Receptor α/IGF1R antibody is IGF-1 Receptor α/IGF1R Antibody (2C8): sc-463.