IFN-α/βRβ Antibody (G-4): sc-376273

IFN-α/βRβ Antibody (G-4) is a mouse monoclonal IgG2b kappa light chain antibody that detects IFN-α/βRβ of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-IFN-α/βRβ antibody (G-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The IFN-α/β receptor complex plays a crucial role in the immune response, mediating the effects of type I interferons, which are vital for establishing an antiviral state in cells. This receptor complex consists of two subunits, IFN-α/βRα and IFN-α/βRβ, with IFN-α/βRβ being essential for high-affinity binding and signal transduction. Type I interferons interact with the IFN-α/β receptor to activate downstream signaling pathways, leading to interferon-stimulated gene expression crucial for antiviral defense and immune regulation. Understanding IFN-α/β receptor complex structure and function helps develop therapeutic strategies against viral infections and autoimmune diseases, while enhancing interferon-based treatment efficacy.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

IFN-α/βRβ Antibody (G-4) References:

1. Determination of residues involved in ligand binding and signal transmission in the human IFN-alpha receptor 2.  |  Chuntharapai, A., et al. 1999. J Immunol. 163: 766-73. PMID: 10395669
2. IFN-alpha receptor mRNA expression in a United States sample with predominantly genotype 1a/I chronic hepatitis C liver biopsies correlates with response to IFN therapy.  |  Mathai, J., et al. 1999. J Interferon Cytokine Res. 19: 1011-8. PMID: 10505743
3. Identification of residues of the IFNAR1 chain of the type I human interferon receptor critical for ligand binding and biological activity.  |  Cajean-Feroldi, C., et al. 2004. Biochemistry. 43: 12498-512. PMID: 15449939
4. The human interferon-gamma receptor. Purification, characterization, and preparation of antibodies.  |  Novick, D., et al. 1987. J Biol Chem. 262: 8483-7. PMID: 2954953
5. Molecular cloning and expression of the human interferon-gamma receptor.  |  Aguet, M., et al. 1988. Cell. 55: 273-80. PMID: 2971451
6. Type I and Type II interferon receptors.  |  Orchansky, P., et al. 1984. J Interferon Res. 4: 275-82. PMID: 6086780
7. Evidence that types I and II interferons have different receptors.  |  Branca, AA. and Baglioni, C. 1981. Nature. 294: 768-70. PMID: 6172715
8. Identification and sequence of an accessory factor required for activation of the human interferon gamma receptor.  |  Soh, J., et al. 1994. Cell. 76: 793-802. PMID: 8124716
9. A novel member of the interferon receptor family complements functionality of the murine interferon gamma receptor in human cells.  |  Hemmi, S., et al. 1994. Cell. 76: 803-10. PMID: 8124717
10. The human interferon alpha/beta receptor: characterization and molecular cloning.  |  Novick, D., et al. 1994. Cell. 77: 391-400. PMID: 8181059
11. Characterization of the alpha subunit of the IFN-alpha receptor. Evidence of N- and O-linked glycosylation and association with other surface proteins.  |  Platanias, LC., et al. 1993. J Immunol. 150: 3382-8. PMID: 8468477
12. Structure-function study of the extracellular domain of the human IFN-alpha receptor (hIFNAR1) using blocking monoclonal antibodies: the role of domains 1 and 2.  |  Lu, J., et al. 1998. J Immunol. 160: 1782-8. PMID: 9469437

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IFN-α/βRβ Antibody (G-4) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-IFN-α/βRβ Antibody (G-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IFN-α/βRβ Antibody (G-4) Specifications

Alternate Product Name: IFN-α/βRβ

Product Clone Name: G-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 79-109

Epitope Target: IFN-α/βRβ

Epitope Species: human

Product Reactivity/Detection: IFN-α/βRβ

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for IFN-α/βRβ Antibody (G-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin