HLA-A Antibody (C-6): sc-365485

HLA-A Antibody (C-6) is a mouse monoclonal IgG2b antibody that detects HLA-A in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). HLA-A plays a crucial role in the immune response by presenting peptide antigens to T lymphocytes, which is essential for the activation of adaptive immunity. Located on the surface of nearly all nucleated cells, HLA-A molecules are vital for the recognition of infected or malignant cells by cytotoxic T cells, thereby facilitating the elimination of these cells from the body. The structure of HLA-A consists of a membrane-anchored heavy chain that forms a heterodimer with beta-2-microglobulin, allowing for presentation of peptides derived from intracellular proteins. The polymorphic nature of HLA-A, with hundreds of alleles identified, contributes to the diversity of immune responses among individuals, making HLA-A a key factor in transplantation compatibility and susceptibility to autoimmune diseases. Anti-HLA-A antibody (C-6) serves as an invaluable tool for researchers studying immune responses, disease mechanisms, and therapeutic interventions.

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HLA-A Antibody (C-6) References:

1. ALVAC-SIV-gag-pol-env-based vaccination and macaque major histocompatibility complex class I (A*01) delay simian immunodeficiency virus SIVmac-induced immunodeficiency.  |  Pal, R., et al. 2002. J Virol. 76: 292-302. PMID: 11739694
2. Characterization of the major histocompatibility complex class I A alleles in cynomolgus macaques of Vietnamese origin.  |  Zhang, GQ., et al. 2012. Tissue Antigens. 80: 494-501. PMID: 23137320
3. An old Twist in HLA-A: CDR3α Hook up at an R65-joint.  |  Murray, JS. 2015. Front Immunol. 6: 268. PMID: 26074926
4. Characterization of a new HLA-A allele, HLA-A*02:07:08, by cloning and sequencing.  |  Wang, WY., et al. 2016. Int J Immunogenet. 43: 109-10. PMID: 26862064
5. The HLA A03 Supertype and Several Pan Species Major Histocompatibility Complex Class I A Allotypes Share a Preference for Binding Positively Charged Residues in the F Pocket: Implications for Controlling Retroviral Infections.  |  de Groot, NG., et al. 2020. J Virol. 94: PMID: 32075930
6. HLA-A*02:411 identified in a platelet donor from China.  |  Li, XF., et al. 2020. HLA. 96: 491-493. PMID: 32725697
7. HLA-A homozygosis is associated with susceptibility to COVID-19.  |  De Marco, R., et al. 2021. HLA. 98: 122-131. PMID: 34165257
8. Identification of neoepitope reactive T-cell receptors guided by HLA-A*03:01 and HLA-A*11:01 immunopeptidomics.  |  Ade, CM., et al. 2023. J Immunother Cancer. 11: PMID: 37758652
9. The HLA-A Allele, HLA-A*11:01:01:07, Identified by Third-Generation Sequencing.  |  Chen, Y., et al. 2024. HLA. 104: e15771. PMID: 39564937
10. Sequence of a cDNA coding for a rat class II A alpha chain: extensive DNA and protein sequence identity to H-2 A alpha and HLA-DC1 alpha chains.  |  Wallis, AE. and McMaster, WR. 1984. Immunogenetics. 19: 53-62. PMID: 6319276

The preferred HLA class I antibody is HLA class I Antibody (HP-1F7): sc-69892.