HGF Antibody (3F203): sc-71244

HGF Antibody (3F203) is a mouse monoclonal IgG1 kappa light chain antibody designed to detect hepatocyte growth factor (HGF), also known as scatter factor, hematopoietin A, or mammary growth factor. HGF is a pivotal pleiotropic growth factor involved in various cellular processes, including cell growth, motility, and morphogenesis, by interacting with its receptor, c-Met. Structurally, HGF is synthesized as a single-chain precursor of 728 amino acids, which includes a 29-amino acid signal peptide that is cleaved to form the mature protein. The biologically active HGF consists of a disulfide-linked α chain and a β chain, both of which are highly glycosylated, a post-translational modification essential for stability, proper folding, and efficient binding to the c-Met receptor. These glycosylation sites are critical as they influence HGF′s interaction with c-Met, thereby regulating downstream signaling pathways that are vital for liver regeneration, wound healing, and embryonic development. HGF monoclonal antibody (3F203) is raised against recombinant human HGF, and is recommended for use in western blotting (WB) to detect human HGF without cross-reacting with other tested cytokines in enzyme-linked immunosorbent assay (ELISA). By enabling precise detection and quantification of HGF, anti-HGF antibody (3F203) supports research into HGF-mediated signaling mechanisms and their roles in both normal physiology and pathological conditions such as cancer, where HGF can promote tumor growth and metastasis. HGF (3F203) antibody is an essential tool for scientists investigating the complex functions of HGF and developing targeted therapeutic strategies, making this resource indispensable for advancing biomedical research and understanding HGF′s impact on health and disease.

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HGF Antibody (3F203) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-HGF Antibody (3F203) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HGF Antibody (3F203) Specifications

Alternate Product Name: Hepatocyte growth factor

Product Clone Name: 3F203

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: HGF

Epitope Species: human

Product Reactivity/Detection: HGF

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for HGF Antibody (3F203): N/A

The preferred HGFα antibody is HGFα Antibody (H-10): sc-374422.