Hemoglobin β Antibody (18): sc-130320

Hemoglobin β Antibody (18) is a mouse monoclonal IgG1 kappa light chain antibody raised against recombinant Hemoglobin β of human origin. Anti-Hemoglobin β antibody (18) specifically detects Hemoglobin β, also known as Hemoglobin subunit β, β-globin, or HBB, in human samples using western blotting (WB), immunoprecipitation (IP), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Hemoglobin β is a critical component of hemoglobin, the oxygen-carrying protein in red blood cells responsible for transporting oxygen from the lungs to tissues throughout the body. Structurally, Hemoglobin β consists of a globin fold with eight alpha helices that pair with alpha globin chains to form the hemoglobin tetramer, each subunit binding a heme group containing an iron ion essential for oxygen binding. The precise arrangement and interaction of these alpha and beta subunits are crucial for the cooperative binding and release of oxygen, a property that enables efficient oxygen delivery to tissues. Alterations in the structure of Hemoglobin β can significantly impact hemoglobin function, leading to disorders such as sickle cell anemia and beta-thalassemia. Understanding the structure and function of Hemoglobin β is therefore vital for studying oxygen transport mechanisms and for the diagnosis and treatment of hemoglobinopathies. Hemoglobin β monoclonal antibody (18) provides a reliable tool for detecting and analyzing Hemoglobin β in various biological assays, facilitating research in hematology and related fields.

The preferred Hemoglobin β antibody is Hemoglobin β Antibody (37-8): sc-21757.