GH Antibody (GH-45): sc-51602

GH Antibody (GH-45) is a mouse monoclonal IgG1 antibody that detects growth hormone (GH) in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-GH antibody (GH-45) plays a vital role in understanding the function of growth hormone, which is essential for stimulating growth, metabolism, and differentiation in numerous mammalian cell types. GH (GH-45) monoclonal antibody achieves its effects by binding to its specific receptor, growth hormone receptor (GHR), initiating a phosphorylation cascade that activates multiple signaling pathways crucial for cellular function. The pulsatile secretion of GH is intricately regulated by hypothalamic factors such as growth hormone-releasing hormone (GHRH) and somatostatin (SRIF), which not only influence GH release from somatotrophs but also modulate synthesis and secretory capacity. Additionally, GH output is subject to feedback regulation by GH levels and insulin-like growth factor I, highlighting the importance of maintaining balanced GH levels for proper physiological function. GH is synthesized in the anterior pituitary gland by acidophilic or somatotropic cells and consists of 191 amino acids linked by two disulfide bridges, a structure that is critical for biological activity and interaction with GHR. GH (GH-45) antibody is therefore an invaluable tool for researchers investigating the complex regulatory mechanisms of growth hormone and its implications in various physiological and pathological conditions.

The preferred GH antibody is GH Antibody (E-7): sc-374266.