GATA-2 Antibody (H-6): sc-515178
- GATA-2 Antibody (H-6) is a mouse monoclonal IgM κ GATA-2 antibody, cited in 6 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 263-287 within an internal region of GATA-2 of human origin
- recommended for detection of GATA-2 of mouse, rat and human origin by WB, IP, IF and ELISA
- available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; phycoerythrin, FITC, Alexa Fluor® 488 or Alexa Fluor® 647 for IF, IHC(P) and FCM
- TransCruz reagent for ChIP application (sc-515178 X, 200 µg/0.1 ml)
- m-IgGκ BP-HRP is the preferred secondary detection reagent for GATA-2 Antibody (H-6) for WB applications. This reagent is now offered in a bundle with GATA-2 Antibody (H-6) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
GATA-2 Antibody (H-6) is a mouse monoclonal IgM antibody that detects GATA-2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-GATA-2 antibody (H-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. GATA-2 plays a crucial role in hematopoiesis and is essential for the development of various blood cell lineages, particularly in the regulation of gene expression during embryonic development. GATA-2 is predominantly expressed in embryonic brain and liver tissues, as well as in endothelial and erythroid cells, highlighting its importance in both developmental and adult hematopoietic processes. GATA-2 interacts with other GATA family members, such as GATA-1 and GATA-3, which are involved in specific lineage differentiation, indicating broader regulatory capabilities. GATA-2 binding to the WGATAR consensus sequence allows modulation of target genes critical for cell fate decisions, making GATA-2 a vital component in transcriptional networks that govern hematopoietic stem cell maintenance and differentiation. Understanding GATA-2 function and interactions is essential for elucidating mechanisms underlying blood cell development and potential implications in hematological disorders.
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GATA-2 Antibody (H-6) References:
- Levels of GATA-1/GATA-2 transcription factors modulate expression of embryonic and fetal hemoglobins. | Ikonomi, P., et al. 2000. Gene. 261: 277-87. PMID: 11167015
- GATA-2 regulates granulocyte-macrophage progenitor cell function. | Rodrigues, NP., et al. 2008. Blood. 112: 4862-73. PMID: 18840712
- GATA-2 reinforces megakaryocyte development in the absence of GATA-1. | Huang, Z., et al. 2009. Mol Cell Biol. 29: 5168-80. PMID: 19620289
- Dendritic cell, monocyte, B and NK lymphoid deficiency defines the lost lineages of a new GATA-2 dependent myelodysplastic syndrome. | Bigley, V. and Collin, M. 2011. Haematologica. 96: 1081-3. PMID: 21810969
- GATA-2 transduces LPS-induced il-1β gene expression in macrophages via a toll-like receptor 4/MD88/MAPK-dependent mechanism. | Wu, TT., et al. 2013. PLoS One. 8: e72404. PMID: 23940812
- Hyperosmolarity-Induced Down-Regulation of Claudin-2 Mediated by Decrease in PKCβ-Dependent GATA-2 in MDCK Cells. | Ikari, A., et al. 2015. J Cell Physiol. 230: 2776-87. PMID: 25825272
- Clioquinol increases the expression of interleukin-8 by down-regulating GATA-2 and GATA-3. | Katsuyama, M., et al. 2018. Neurotoxicology. 67: 296-304. PMID: 29966605
- Human leukemia mutations corrupt but do not abrogate GATA-2 function. | Katsumura, KR., et al. 2018. Proc Natl Acad Sci U S A. 115: E10109-E10118. PMID: 30301799
- GATA-2-deficient mast cells limit IgE-mediated immediate hypersensitivity reactions in human subjects. | Desai, A., et al. 2019. J Allergy Clin Immunol. 144: 613-617.e14. PMID: 31102699
- GATA 2 Haploinsufficiency in Acute Myeloid Leukemia: Looking Beyond the Obvious. | Radhakrishnan, N., et al. 2020. Indian Pediatr. 57: 570-571. PMID: 32562402
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GATA-2 Antibody (H-6) | sc-515178 | 200 µg/ml | $322.00 | |||
GATA-2 Antibody (H-6): m-IgGκ BP-HRP Bundle | sc-552716 | 200 µg Ab; 40 µg BP | $361.00 | |||
GATA-2 Antibody (H-6) AC | sc-515178 AC | 500 µg/ml, 25% agarose | $424.00 | |||
GATA-2 Antibody (H-6) Alexa Fluor® 488 | sc-515178 AF488 | 200 µg/ml | $364.00 | |||
GATA-2 Antibody (H-6) Alexa Fluor® 647 | sc-515178 AF647 | 200 µg/ml | $364.00 | |||
GATA-2 Antibody (H-6) FITC | sc-515178 FITC | 200 µg/ml | $336.00 | |||
GATA-2 Antibody (H-6) HRP | sc-515178 HRP | 200 µg/ml | $322.00 | |||
GATA-2 (H-6) Neutralizing Peptide | sc-515178 P | 100 µg/0.5 ml | $69.00 | |||
GATA-2 Antibody (H-6) PE | sc-515178 PE | 200 µg/ml | $349.00 | |||
GATA-2 Antibody (H-6) X | sc-515178 X | 200 µg/0.1 ml | $322.00 |