Molecular structure of Ganglioside GD1a disodium salt, CAS Number: 12707-58-3
Ganglioside GD1a disodium salt (CAS 12707-58-3)
See product citations (3)
Alternate Names:
Disialoganglioside GD1a•2Na
Application:
Ganglioside GD1a disodium salt is an agent with a stimulatory effect on phagocytosis and phagosome-lysosome
CAS Number:
12707-58-3
Purity:
98%
Molecular Weight:
1882.04
Molecular Formula:
C84H146N4O39•2Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ganglioside GD1a disodium salt is the major ganglioside in the mammalian brain. Believed to be a differentiation marker for stem cell growth. Has shown a stimulatory effect on phagocytosis and phagosome-lysosome (P-L) fusion in a dose-dependent manner on S. aureus. Shown to modulate the Ca-dependent post-translational regulation of GAP-43. Shown to induce rapid phosphorylation of GAP-43 and stimulate ca-dependent proteolysis of GAP-43. Ganglioside GD1a disodium salt is an inhibitor of PKC.
Ganglioside GD1a disodium salt (CAS 12707-58-3) References
- Human gangliosides and bacterial lipo-oligosaccharides in the development of autoimmune neuropathies. | Yuki, N. 2010. Methods Mol Biol. 600: 51-65. PMID: 19882120
- Ganglioside GD1a suppresses LPS-induced pro-inflammatory cytokines in RAW264.7 macrophages by reducing MAPKs and NF-κB signaling pathways through TLR4. | Wang, Y., et al. 2015. Int Immunopharmacol. 28: 136-45. PMID: 26054879
- Virucidal nano-perforator of viral membrane trapping viral RNAs in the endosome. | Kong, B., et al. 2019. Nat Commun. 10: 185. PMID: 30643128
- Bifunctional hetero di-disc for broad-spectrum influenza neutralization. | Moon, S., et al. 2022. Nanomedicine. 44: 102587. PMID: 35863620
- Adhesion energy controls lipid binding-mediated endocytosis. | Groza, R., et al. 2024. Nat Commun. 15: 2767. PMID: 38553473
- Effects of gangliosides GM1 and GD1a on GAP-43 phosphorylation and dephosphorylation in isolated growth cones. | Meiri, KF. and Beverly, M. 1994. J Neurochem. 62: 291-9. PMID: 8263528
- Stimulatory effect of gangliosides on phagocytosis, phagosome-lysosome fusion, and intracellular signal transduction system by human polymorphonuclear leukocytes. | Yamaguchi, S., et al. 1997. Glycoconj J. 14: 707-14. PMID: 9337083
Inhibitor of:
PKC, and Ser/Thr Protein Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ganglioside GD1a disodium salt, 1 mg | sc-202621 | 1 mg | $90.00 | |||
Ganglioside GD1a disodium salt, 5 mg | sc-202621A | 5 mg | $300.00 |