galectin-7 Antibody (F-3): sc-271472
- galectin-7 Antibody (F-3) is a mouse monoclonal IgM κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 41-91 within an internal region of galectin-7 of human origin
- recommended for detection of galectin-7 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for galectin-7 Antibody (F-3). This work is in progress.
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galectin-7 Antibody (F-3) is a mouse monoclonal IgM antibody that detects galectin-7 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Galectin-7 is a member of the galectin family, which consists of soluble β-galactoside-binding lectins that play crucial roles in cellular processes such as cell adhesion, apoptosis, and tumor progression. Galectin-7 is predominantly expressed in stratified squamous epithelium and is known for pro-apoptotic function, acting upstream of c-Jun N-terminal kinase (JNK) activation and cytochrome c release, which are vital for the apoptotic signaling pathway. Galectin-7 regulation is tightly controlled, as galectin-7 is activated by the tumor suppressor protein p53 and repressed by retinoic acid, highlighting its importance in maintaining cellular homeostasis and responding to stress signals. The galectin-7 gene is located on chromosome 19, and galectin-7 interactions with other proteins can influence various cellular functions, making galectin-7 a significant target for research in cancer biology and therapeutic development. Anti-galectin-7 antibody (F-3) provides a reliable tool for studying the expression and function of galectin-7 in various biological contexts.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
galectin-7 Antibody (F-3) References:
- Ras inhibition boosts galectin-7 at the expense of galectin-1 to sensitize cells to apoptosis. | Barkan, B., et al. 2013. Oncotarget. 4: 256-68. PMID: 23530091
- Galectin-7 levels predict radiation response in squamous cell carcinoma of the cervix. | Tsai, CJ., et al. 2013. Gynecol Oncol. 131: 645-9. PMID: 23643871
- Galectin-7 is epigenetically-regulated tumor suppressor in gastric cancer. | Kim, SJ., et al. 2013. Oncotarget. 4: 1461-71. PMID: 23985992
- Galectin-7 acts as an adhesion molecule during implantation and increased expression is associated with miscarriage. | Menkhorst, EM., et al. 2014. Placenta. 35: 195-201. PMID: 24522232
- Galectin-7 serum levels are altered prior to the onset of pre-eclampsia. | Menkhorst, E., et al. 2014. Placenta. 35: 281-5. PMID: 24534543
- Expression and functions of galectin-7 in ovarian cancer. | Labrie, M., et al. 2014. Oncotarget. 5: 7705-21. PMID: 25277199
- Clinical significance of galectin-7 in vulvar squamous cell carcinoma. | Jiang, Y., et al. 2015. Oncol Lett. 10: 3826-3831. PMID: 26788216
- Galectin-7 promotes the invasiveness of human oral squamous cell carcinoma cells via activation of ERK and JNK signaling. | Guo, JP. and Li, XG. 2017. Oncol Lett. 13: 1919-1924. PMID: 28454344
- Expression of galectin-7 in vulvar lichen sclerosus and its effect on dermal fibroblasts. | Zhao, Y., et al. 2018. Oncol Lett. 16: 2559-2564. PMID: 30013650
- Innate immune Galectin-7 specifically targets microbes that decorate themselves in blood group-like antigens. | Wu, SC., et al. 2022. iScience. 25: 104482. PMID: 35754739
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
galectin-7 Antibody (F-3) | sc-271472 | 200 µg/ml | $322.00 | |||
galectin-7 (F-3) Neutralizing Peptide | sc-271472 P | 100 µg/0.5 ml | $69.00 |