GABA_A Rα1-6 Antibody (E-8): sc-376282

GABAA Rα1-6 Antibody (E-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects GABAA R alpha 1-6 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GABAA Rα1-6 (E-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. GABAA R alpha 1-6 protein plays a crucial role in the central nervous system as a subunit of the GABAA receptor, which mediates the inhibitory effects of gamma-aminobutyric acid (GABA). This receptor maintains the balance between neuronal excitation and inhibition, influencing physiological processes such as anxiety, sleep, and muscle relaxation. GABAA receptor forms a pentameric structure composed of different subunits, including alpha, beta, and gamma types, contributing to functional diversity and pharmacological properties. Specific arrangement of these subunits can affect GABAA receptor′s response to GABA and other modulators, making GABAA R alpha 1-6 essential for understanding neuropharmacology and potential therapeutic targets for neurological disorders.

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GABA_A Rα1-6 Antibody (E-8) References:

1. Molecular heterogeneity of the gamma-aminobutyric acid (GABA) transport system. Cloning of two novel high affinity GABA transporters from rat brain.  |  Borden, LA., et al. 1992. J Biol Chem. 267: 21098-104. PMID: 1400419
2. GABA: an excitatory transmitter in early postnatal life.  |  Cherubini, E., et al. 1991. Trends Neurosci. 14: 515-9. PMID: 1726341
3. Cloning of the human brain GABA transporter.  |  Nelson, H., et al. 1990. FEBS Lett. 269: 181-4. PMID: 2387399
4. Targeting of the 67-kDa isoform of glutamic acid decarboxylase to intracellular organelles is mediated by its interaction with the NH2-terminal region of the 65-kDa isoform of glutamic acid decarboxylase.  |  Dirkx, R., et al. 1995. J Biol Chem. 270: 2241-6. PMID: 7836456
5. GABAC receptors in the vertebrate retina.  |  Lukasiewicz, PD. 1996. Mol Neurobiol. 12: 181-94. PMID: 8884747
6. Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.  |  Kaupmann, K., et al. 1997. Nature. 386: 239-46. PMID: 9069281
7. GABA(A)-receptor subtypes: clinical efficacy and selectivity of benzodiazepine site ligands.  |  Korpi, ER., et al. 1997. Ann Med. 29: 275-82. PMID: 9375983

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GABA_A Rα1-6 Antibody (E-8) has 14 citations in a variety of scientific publications.

Primary antibodies like Anti-GABA_A Rα1-6 Antibody (E-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GABA_A Rα1-6 Antibody (E-8) Specifications

Alternate Product Name: GABRA1

Product Clone Name: E-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 157-456

Epitope Target: GABAA Rα1

Epitope Species: human

Product Reactivity/Detection: GABA_A Rα1, GABA_A Rα2, GABA_A Rα3, GABA_A Rα4, GABA_A Rα5 and GABA_A Rα6

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 14 citations in various scientific publications

Available Conjugates/Forms for GABA_A Rα1-6 Antibody (E-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred GABA_A Rα5 antibody is GABA_A Rα5 Antibody (A-5): sc-393921.