Molecular structure of Epz004777, CAS Number: 1338466-77-5
Epz004777 (CAS 1338466-77-5)
Alternate Names:
1-[3-[[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxyoxolan-2-yl]methyl-propan-2-ylamino]propyl]-3-(4-tert-butylphenyl)urea
CAS Number:
1338466-77-5
Molecular Weight:
539.7
Molecular Formula:
C28H41N7O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Epz004777 (CAS 1338466-77-5) References
- Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor. | Daigle, SR., et al. 2011. Cancer Cell. 20: 53-65. PMID: 21741596
- Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors. | Yu, W., et al. 2012. Nat Commun. 3: 1288. PMID: 23250418
- Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l. | Deshpande, AJ., et al. 2013. Blood. 121: 2533-41. PMID: 23361907
- DOT1L inhibitor improves early development of porcine somatic cell nuclear transfer embryos. | Tao, J., et al. 2017. PLoS One. 12: e0179436. PMID: 28632762
- Design, synthesis and in vitro anti-Zika virus evaluation of novel Sinefungin derivatives. | Tao, Z., et al. 2018. Eur J Med Chem. 157: 994-1004. PMID: 30170321
- Inhibition of Disruptor of Telomeric Silencing 1-Like Alleviated Renal Ischemia and Reperfusion Injury-Induced Fibrosis by Blocking PI3K/AKT-Mediated Oxidative Stress. | Yang, C., et al. 2019. Drug Des Devel Ther. 13: 4375-4387. PMID: 31920287
- Dot1l Aggravates Keratitis Induced by Herpes Simplex Virus Type 1 in Mice via p38 MAPK-Mediated Oxidative Stress. | Wan, S., et al. 2021. Oxid Med Cell Longev. 2021: 6612689. PMID: 33628364
- Synthesis and Profiling of Highly Selective Inhibitors of Methyltransferase DOT1L Based on Carbocyclic C-Nucleosides. | Khirsariya, P., et al. 2022. J Med Chem. 65: 5701-5723. PMID: 35302777
- Identification of EPZ004777 and FG2216 as inhibitors of TGF-β1 induced Treg cells by screening a library of epigenetic compounds. | Premkumar, K. and Shankar, BS. 2022. Life Sci. 301: 120643. PMID: 35569570
- DOT1L regulates MTDH-mediated angiogenesis in triple-negative breast cancer: intermediacy of NF-κB-HIF1α axis. | Neeli, PK., et al. 2023. FEBS J. 290: 502-520. PMID: 36017623
Inhibitor of:
4832428D23Rik, Ada1, AEBP2, AI931714, ASH1L, DOT1L1, EHMT1, ESCO1, FAM119A, H3-K9-HMTase, Histone cluster 1 H4J, Histone cluster 3 H3, Histone H2A.Z, ICAD, KIAA1429, KMT5 (lysine methyltransferase), L3MBTL3, METTL12, METTL2, METTL25, MLLT (Mixed Lineage Leukemia Translocated), MOF, NSD2, PA1, PHF23, Polycomb, PRDM6, RNMT, SET7/9, Sp9, Swi3, TADA2B, TADA2L, TGIF2, TMEM59, Trimethyl Histone H4, and YTHDF2.Activator of:
ACTR6, AF-10, ASH2L, C11orf41_D430041D05Rik, E430018J23Rik, EID-3, GLTSCR1, INTS4, JMJD4, LRRC4B, MLL4, Monomethyl Histone H4, NSD3, plexin-A4, RTF1, Set2, TAF9A, THAP10, TMEM147, and ZSCAN18.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Epz004777, 100 mg | sc-507560 | 100 mg | $575.00 |