ephrin-B3 Antibody (D-11): sc-390696

ephrin-B3 Antibody (D-11) is a mouse monoclonal IgG2a kappa light chain antibody that detects ephrin-B3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ephrin-B3 Antibody (D-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ephrin-B3 plays a crucial role in cell signaling and communication, particularly in nervous system development, where ephrin-B3 is involved in regulating neuronal growth and guidance. ephrin-B3 interacts with EphB receptors, which are essential for mediating cell-cell interactions during embryonic development and maintaining adult tissue architecture. ephrin-B3 functions are vital for processes such as synaptic plasticity and neural network formation, making ephrin-B3 a significant target for research in neurobiology and developmental biology. Understanding ephrin-B3 interactions and signaling pathways can provide insights into various neurological disorders and potential therapeutic approaches.

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ephrin-B3 Antibody (D-11) References:

1. Ephrin-B3 decreases the survival of adult rat spinal cord-derived neural stem/progenitor cells in vitro and after transplantation into the injured rat spinal cord.  |  Fan, XY., et al. 2013. Stem Cells Dev. 22: 359-73. PMID: 22900481
2. Ephrin B3 interacts with multiple EphA receptors and drives migration and invasion in non-small cell lung cancer.  |  Efazat, G., et al. 2016. Oncotarget. 7: 60332-60347. PMID: 27533087
3. Ephrin-B3 controls excitatory synapse density through cell-cell competition for EphBs.  |  Henderson, NT., et al. 2019. Elife. 8: PMID: 30789343
4. Registry of Compartmental Ephrin-B3 Guidance Patterns With Respect to Emerging Multimodal Midbrain Maps.  |  Stinson, JPC., et al. 2021. Front Neuroanat. 15: 649478. PMID: 33815071
5. In silico prediction of interaction between Nipah virus attachment glycoprotein and host cell receptors Ephrin-B2 and Ephrin-B3 in domestic and peridomestic mammals.  |  Hoque, AF., et al. 2023. Infect Genet Evol. 116: 105516. PMID: 37924857
6. Identification and cloning of ELF-1, a developmentally expressed ligand for the Mek4 and Sek receptor tyrosine kinases.  |  Cheng, HJ. and Flanagan, JG. 1994. Cell. 79: 157-68. PMID: 7522971
7. ELF-2, a new member of the Eph ligand family, is segmentally expressed in mouse embryos in the region of the hindbrain and newly forming somites.  |  Bergemann, AD., et al. 1995. Mol Cell Biol. 15: 4921-9. PMID: 7651410
8. Cloning of AL-1, a ligand for an Eph-related tyrosine kinase receptor involved in axon bundle formation.  |  Winslow, JW., et al. 1995. Neuron. 14: 973-81. PMID: 7748564
9. Ligands for the receptor tyrosine kinases hek and elk: isolation of cDNAs encoding a family of proteins.  |  Kozlosky, CJ., et al. 1995. Oncogene. 10: 299-306. PMID: 7838529
10. Molecular characterization of a family of ligands for eph-related tyrosine kinase receptors.  |  Beckmann, MP., et al. 1994. EMBO J. 13: 3757-62. PMID: 8070404
11. B61 is a ligand for the ECK receptor protein-tyrosine kinase.  |  Bartley, TD., et al. 1994. Nature. 368: 558-60. PMID: 8139691
12. Elk-L3, a novel transmembrane ligand for the Eph family of receptor tyrosine kinases, expressed in embryonic floor plate, roof plate and hindbrain segments.  |  Gale, NW., et al. 1996. Oncogene. 13: 1343-52. PMID: 8808709

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ephrin-B3 Antibody (D-11) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-ephrin-B3 Antibody (D-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ephrin-B3 Antibody (D-11) Specifications

Alternate Product Name: ephrin-B3

Product Clone Name: D-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 2-21

Epitope Target: ephrin-B3

Epitope Species: human

Product Reactivity/Detection: ephrin-B3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for ephrin-B3 Antibody (D-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin