E-Selectin/CD62E/SELE Antibody (UZ5): sc-59765
- E-Selectin/CD62E/SELE Antibody (UZ5) is a rat monoclonal IgG2b, cited in 2 publications, provided at 200 µg/ml
- raised against LPS activated mlEND1 cells expressing E selectin at their cell surface of mouse oirgin
- recommended for detection of E-Selectin of mouse origin by WB, IP and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for E-Selectin/CD62E/SELE Antibody (UZ5). This work is in progress.
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E-Selectin Antibody (UZ5) is a rat monoclonal IgG2b antibody that detects E-Selectin in mouse samples through applications such as western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). E-Selectin, also known as ELAM-1 or CD62E, is a crucial adhesion molecule expressed on the surface of endothelial cells, particularly in response to pro-inflammatory cytokines. E-Selectin′s primary function is to mediate the adhesion of leukocytes to the vascular endothelium during inflammatory responses, which is vital for the recruitment of immune cells to sites of injury or infection. Expression of E-Selectin is tightly regulated and occurs primarily in activated endothelial cells, making E-Selectin a key player in the inflammatory process. By facilitating the rolling and adhesion of leukocytes, E-Selectin plays an essential role in the immune response, influencing both the magnitude and duration of inflammation. Anti-E-Selectin antibody (UZ5) serves as an invaluable tool for researchers studying vascular biology and immune responses, providing insights into the mechanisms of cell adhesion and the pathophysiology of inflammatory diseases.
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E-Selectin/CD62E/SELE Antibody (UZ5) References:
- E-selectin is required for the antiangiogenic activity of endostatin. | Yu, Y., et al. 2004. Proc Natl Acad Sci U S A. 101: 8005-10. PMID: 15148373
- Ser128Arg E-selectin and Thr715Pro P-selectin polymorphisms and severe preeclampsia. | Derzbach, L., et al. 2007. J Reprod Med. 52: 815-8. PMID: 17939599
- E-selectin targeting to visualize tumors in vivo. | Hirai, M., et al. 2010. Contrast Media Mol Imaging. 5: 70-7. PMID: 20235150
- P-selectin, E-selectin, and CD40L over time in chronic hemodialysis patients. | Bossola, M., et al. 2012. Hemodial Int. 16: 38-46. PMID: 22099468
- Comparison of human and mouse E-selectin binding to Sialyl-Lewis(x). | Rocheleau, AD., et al. 2016. BMC Struct Biol. 16: 10. PMID: 27368167
- E-selectin ligands recognised by HECA452 induce drug resistance in myeloma, which is overcome by the E-selectin antagonist, GMI-1271. | Natoni, A., et al. 2017. Leukemia. 31: 2642-2651. PMID: 28439107
- E-selectin-mediated rolling facilitates pancreatic cancer cell adhesion to hyaluronic acid. | Shea, DJ., et al. 2017. FASEB J. 31: 5078-5086. PMID: 28765175
- The role of soluble E-selectin in HIV associated preeclampsia. | Naidoo, G., et al. 2021. Eur J Obstet Gynecol Reprod Biol. 257: 64-69. PMID: 33360241
- Disposition of E-selectin-targeting liposomes in tumor spheroids with a perfusable vascular network. | Chantarasrivong, C., et al. 2022. Drug Metab Pharmacokinet. 47: 100469. PMID: 36174354
- Distinct phenotype of E-selectin-deficient mice. E-selectin is required for slow leukocyte rolling in vivo. | Kunkel, EJ. and Ley, K. 1996. Circ Res. 79: 1196-204. PMID: 8943958
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
E-Selectin/CD62E/SELE Antibody (UZ5) | sc-59765 | 200 µg/ml | $322.00 | |||
E-Selectin/CD62E/SELE Antibody (UZ5) FITC | sc-59765 FITC | 200 µg/ml | $336.00 | |||
E-Selectin/CD62E/SELE Antibody (UZ5) PE | sc-59765 PE | 200 µg/ml | $349.00 |