DGAT Inibitori per le analisi funzionali delle risposte cellulari a DGAT
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Animal Health Prescription Item
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Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
DGAT1 Antibody (A-5) is a high quality monoclonal DGAT1 antibody (also designated DGAT1 antibody) suitable for the detection of the DGAT1 protein of human origin. DGAT1 Antibody (A-5) is available as both the non-conjugated anti-DGAT1 antibody form, as well as multiple conjugated forms of anti-DGAT1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Glucose and insulin are anabolic signals which upregulate the transcriptions of a series of lipogenic enzymes to convert excess carbohydrate into triglycerides for efficient energy storage. Acyl-coenzyme A:diacylglycerol acyltransferase, also known as DGAT1 and ARGP1, is a microsomal enzyme that assists in the synthesid of fatty acids into triglycerides. DGAT1 catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol (DAG) and fatty acyl CoA as substrates. DGAT1 plays a fundamental role in the metabolism of cellular diacylglycerol and is important in higher eukaryotes for physiologic processes involving triacylglycerol metabolism such as intestinal fat absorption, lipoprotein assembly, adipose tissue formation, and lactation. DGAT1 is involved in fat absorption in the intestine and in basal level triglyceride synthesis in adipose tissue, where it is more highly expressed. Mice lacking DGAT1 have increased energy expenditure and therefore are resistant to obesity. In addition, mice lacking both copies of DGAT1 are completely devoid of milk secretion, most likely because of deficient triglyceride synthesis in the mammary gland.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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