Molecular structure of CVT-313, CAS Number: 199986-75-9
CVT-313 (CAS 199986-75-9)
See product citations (17)
Alternate Names:
CVT-313 is also known as Cdk2 Inhibitor III.
Application:
CVT-313 is a cell-permeable purine analog that acts as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk2.
CAS Number:
199986-75-9
Purity:
≥98%
Molecular Weight:
400.5
Molecular Formula:
C20H28N6O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
CVT-313 is a cell-permeable purine analog that acts as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk2 (IC50 = 0.5 µM for Cdk2/A and Cdk2/E 4.2 µM for Cdk1/B 215 µM for Cdk4/D1). CVT-313 inhibits other kinases only at much higher concentrations (IC50 > 1.25 mM for MAPK, PKA, and PKC). Additionally, CVT-313 is shown to induce tumor cells growth arrest (IC50 ~1.25-20 µM) in vitro. By halting the cell cycle, CVT-313 suppresses the growth of cancer cells. Furthermore, studies using CVT-313 have explored the interplay between CDK2 and other cellular pathways, including DNA repair mechanisms and apoptosis (programmed cell death).
CVT-313 (CAS 199986-75-9) References
- ATP-site directed inhibitors of cyclin-dependent kinases. | Gray, N., et al. 1999. Curr Med Chem. 6: 859-75. PMID: 10495356
- Histone H1 phosphorylation by Cdk2 selectively modulates mouse mammary tumor virus transcription through chromatin remodeling. | Bhattacharjee, RN., et al. 2001. Mol Cell Biol. 21: 5417-25. PMID: 11463824
- Inhibition of cyclin-dependent kinase-2 induces apoptosis in human diffuse large B-cell lymphomas. | Faber, AC. and Chiles, TC. 2007. Cell Cycle. 6: 2982-9. PMID: 18156799
- Global changes in and characterization of specific sites of phosphorylation in mouse and human histone H1 Isoforms upon CDK inhibitor treatment using mass spectrometry. | Deterding, LJ., et al. 2008. J Proteome Res. 7: 2368-79. PMID: 18416567
- Cell cycle-dependent phosphorylation of human CDC5 regulates RNA processing. | Gräub, R., et al. 2008. Cell Cycle. 7: 1795-803. PMID: 18583928
- CDK2 differentially controls normal cell senescence and cancer cell proliferation upon exposure to reactive oxygen species. | Hwang, CY., et al. 2012. Biochem Biophys Res Commun. 425: 94-9. PMID: 22819841
- Critical reanalysis of the methods that discriminate the activity of CDK2 from CDK1. | Sakurikar, N. and Eastman, A. 2016. Cell Cycle. 15: 1184-8. PMID: 26986210
- A novel and effective inhibitor combination involving bortezomib and OTSSP167 for breast cancer cells in light of label-free proteomic analysis. | Okur, E. and Yerlikaya, A. 2019. Cell Biol Toxicol. 35: 33-47. PMID: 29948483
- Differential Sensitivity to CDK2 Inhibition Discriminates the Molecular Mechanisms of CHK1 Inhibitors as Monotherapy or in Combination with the Topoisomerase I Inhibitor SN38. | Warren, NJH., et al. 2019. ACS Pharmacol Transl Sci. 2: 168-182. PMID: 32259055
- Structure of cyclin-dependent kinase 2 (CDK2) in complex with the specific and potent inhibitor CVT-313. | Talapati, SR., et al. 2020. Acta Crystallogr F Struct Biol Commun. 76: 350-356. PMID: 32744246
- Identification of selective cyclin-dependent kinase 2 inhibitor from the library of pyrrolone-fused benzosuberene compounds: an in silico exploration. | Singh, R., et al. 2022. J Biomol Struct Dyn. 40: 7693-7701. PMID: 33749525
- A network pharmacology approach to investigate the anticancer mechanism of cinobufagin against hepatocellular carcinoma via downregulation of EGFR-CDK2 signaling. | Yang, AL., et al. 2021. Toxicol Appl Pharmacol. 431: 115739. PMID: 34619160
- CVT-313, a specific and potent inhibitor of CDK2 that prevents neointimal proliferation. | Brooks, EE., et al. 1997. J Biol Chem. 272: 29207-11. PMID: 9360999
Inhibitor of:
AK7, ALG6, Cdk, Cdk1/Cdk2, Cdk2, Cdx2, Clb2, Clb3, cyclin G2, DOC1, PTPN20, and RG9MTD1.Activator of:
α-Glucosidase, ACTA1, and LERK-3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CVT-313, 1 mg | sc-221445 | 1 mg | $104.00 | |||
CVT-313, 5 mg | sc-221445A | 5 mg | $416.00 | |||
CVT-313, 50 mg | sc-221445B | 50 mg | $2601.00 |