Coronin 1C Antibody (G-R2): sc-130448
- Coronin 1C Antibody (G-R2) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 100 µg/ml
- raised against recombinant Coronin 1C of human origin
- recommended for detection of Coronin 1C of mouse, rat and human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Coronin 1C Antibody (G-R2). This work is in progress.
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Coronin 1C Antibody (G-R2) is a mouse monoclonal IgG2a antibody that detects Coronin 1C in mouse, rat, and human samples through western blotting (WB) and immunoprecipitation (IP) applications. Coronin 1C, also known as Coronin 3 or HCRNN4, plays a crucial role in the development and function of the nervous system, particularly in differentiating Neuro-2a cells, PC-12 cells, and primary oligodendrocytes, where Coronin 1C influences neuron morphogenesis and migration. Coronin 1C is primarily localized in the cytoplasm and regulates actin dynamics, which maintains the structural integrity of neurons and facilitates movement during development. Coronin 1C′s interaction with the actin cytoskeleton underscores its importance in cellular processes such as growth cone dynamics and synaptic plasticity, which are critical for proper neuronal function and connectivity. Anti-Coronin 1C antibody (G-R2) enables researchers to gain insights into mechanisms underlying neuronal development and potential implications of Coronin 1C dysregulation in neurodegenerative diseases.
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Coronin 1C Antibody (G-R2) References:
- Expression of coronin-3 (coronin-1C) in diffuse gliomas is related to malignancy. | Thal, D., et al. 2008. J Pathol. 214: 415-24. PMID: 18189330
- Coronin 1C harbours a second actin-binding site that confers co-operative binding to F-actin. | Chan, KT., et al. 2012. Biochem J. 444: 89-96. PMID: 22364218
- Knockdown of Coronin-1C disrupts Rac1 activation and impairs tumorigenic potential in hepatocellular carcinoma cells. | Wang, ZG., et al. 2013. Oncol Rep. 29: 1066-72. PMID: 23292607
- Coronin-1C and RCC2 guide mesenchymal migration by trafficking Rac1 and controlling GEF exposure. | Williamson, RC., et al. 2014. J Cell Sci. 127: 4292-307. PMID: 25074804
- Integration of the Rac1- and actin-binding properties of Coronin-1C. | Tilley, FC., et al. 2015. Small GTPases. 6: 36-42. PMID: 25862165
- Coronin-1C Protein and Caveolin Protein Provide Constitutive and Inducible Mechanisms of Rac1 Protein Trafficking. | Williamson, RC., et al. 2015. J Biol Chem. 290: 15437-15449. PMID: 25925950
- Coronin 1c and F-actin Promote Metastasis of Breast Cancer. | Shao, J., et al. 2018. Med Sci Monit. 24: 5980-5987. PMID: 30150608
- Coronin 1C inhibits melanoma metastasis through regulation of MT1-MMP-containing extracellular vesicle secretion. | Tagliatela, AC., et al. 2020. Sci Rep. 10: 11958. PMID: 32686704
- Coronin1C Is a GDP-Specific Rab44 Effector That Controls Osteoclast Formation by Regulating Cell Motility in Macrophages. | Yamaguchi, Y., et al. 2022. Int J Mol Sci. 23: PMID: 35743062
- Coronin 1C restricts endosomal branched actin to organize ER contact and endosome fission. | Striepen, JF. and Voeltz, GK. 2022. J Cell Biol. 221: PMID: 35802042
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Coronin 1C Antibody (G-R2) | sc-130448 | 100 µg/ml | $339.00 |