Coronin 1C Antibody (D-9): sc-376919

Coronin 1C Antibody (D-9) is a mouse monoclonal IgM antibody that detects Coronin 1C of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-Coronin 1C antibody (D-9) is available as a non-conjugated format. Coronin 1C, also known as Coronin 3, plays a crucial role in regulating actin dynamics and is predominantly located in the cytoplasm, particularly at the leading edge of migrating cells. This localization is vital for function in cell motility and cytoskeletal rearrangement, as Coronin 1C helps coordinate the assembly and disassembly of actin filaments, which are essential for various cellular processes, including migration, phagocytosis, and the formation of cellular protrusions. Coronin 1C′s ability to interact with other actin-binding proteins, such as the Arp2/3 complex, further underscores importance in orchestrating the cytoskeletal architecture necessary for effective cellular movement and response to environmental cues. Additionally, Coronin 1C is abundant in differentiating neuronal cells, where Coronin 1C is believed to influence neuron morphogenesis and migration, highlighting significance in neurodevelopmental processes. With diverse roles in cellular dynamics and structure, Coronin 1C antibody (D-9) serves as an essential tool for researchers studying cytoskeletal regulation and cell motility in various biological contexts.

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Coronin 1C Antibody (D-9) References:

1. Coronin localizes to leading edges and is involved in cell spreading and lamellipodium extension in vertebrate cells.  |  Mishima, M. and Nishida, E. 1999. J Cell Sci. 112 (Pt 17): 2833-42. PMID: 10444378
2. Oligomerization, F-actin interaction, and membrane association of the ubiquitous mammalian coronin 3 are mediated by its carboxyl terminus.  |  Spoerl, Z., et al. 2002. J Biol Chem. 277: 48858-67. PMID: 12377779
3. Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1.  |  Yoon, HG., et al. 2003. EMBO J. 22: 1336-46. PMID: 12628926
4. Coronin 7, the mammalian POD-1 homologue, localizes to the Golgi apparatus.  |  Rybakin, V., et al. 2004. FEBS Lett. 573: 161-7. PMID: 15327992
5. Association of the leukocyte plasma membrane with the actin cytoskeleton through coiled coil-mediated trimeric coronin 1 molecules.  |  Gatfield, J., et al. 2005. Mol Biol Cell. 16: 2786-98. PMID: 15800061
6. Coronin 3 and its role in murine brain morphogenesis.  |  Hasse, A., et al. 2005. Eur J Neurosci. 21: 1155-68. PMID: 15813925
7. Coronin-1 function is required for phagosome formation.  |  Yan, M., et al. 2005. Mol Biol Cell. 16: 3077-87. PMID: 15829569
8. Coronin proteins as multifunctional regulators of the cytoskeleton and membrane trafficking.  |  Rybakin, V. and Clemen, CS. 2005. Bioessays. 27: 625-32. PMID: 15892111
9. Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility.  |  Cai, L., et al. 2005. J Biol Chem. 280: 31913-23. PMID: 16027158
10. Coronin-1C is a novel biomarker for hepatocellular carcinoma invasive progression identified by proteomics analysis and clinical validation.  |  Wu, L., et al. 2010. J Exp Clin Cancer Res. 29: 17. PMID: 20181269
11. Coronin 1C promotes triple-negative breast cancer invasiveness through regulation of MT1-MMP traffic and invadopodia function.  |  Castagnino, A., et al. 2018. Oncogene. 37: 6425-6441. PMID: 30065298
12. Coronin 1C, Regulated by Multiple microRNAs, Facilitates Cancer Cell Aggressiveness in Pancreatic Ductal Adenocarcinoma.  |  Fukuda, K., et al. 2023. Genes (Basel). 14: PMID: 37239355

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Coronin 1C Antibody (D-9) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-Coronin 1C Antibody (D-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Coronin 1C Antibody (D-9) Specifications

Alternate Product Name: CORO1C

Product Clone Name: D-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 390-474

Epitope Target: Coronin 1C

Epitope Species: human

Product Reactivity/Detection: Coronin 1C

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for Coronin 1C Antibody (D-9): N/A