CD2 Antibody (TS2/18): sc-81732
- CD2 Antibody (TS2/18) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against human cytolytic T lymphocytes
- recommended for detection of CD2 of human origin by WB, IP, IF and FCM
- available conjugated to FITC for IF, IHC(P) and FCM
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for CD2 Antibody (TS2/18) for WB applications. These reagents are now offered in bundles with CD2 Antibody (TS2/18) (see ordering information below).
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CD2 Antibody (TS2/18) is a mouse monoclonal IgG1 antibody that detects CD2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). CD2 is a crucial transmembrane glycoprotein primarily expressed on peripheral blood T lymphocytes, natural killer (NK) cells, and thymocytes, as well as on mouse B cells and rat splenic macrophages. CD2 plays a vital role in the immune response by mediating cell adhesion through interaction with the CD58 ligand, which enhances antigen-specific T cell activation. The binding of CD2 to CD58 optimizes immune system recognition, facilitating effective communication between helper T lymphocytes and antigen-presenting cells, as well as between cytolytic effectors and target cells. The importance of CD2 in immune signaling underscores potential as a therapeutic target in various immunological disorders. Anti-CD2 antibody (TS2/18) is an essential tool for researchers aiming to explore the dynamics of immune cell interactions and the underlying mechanisms of T cell activation.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CD2 Antibody (TS2/18) References:
- Cloning, expression, and function of BLAME, a novel member of the CD2 family. | Kingsbury, GA., et al. 2001. J Immunol. 166: 5675-80. PMID: 11313408
- Enhancer role of STAT5 in CD2 activation of IFN-gamma gene expression. | Gonsky, R., et al. 2004. J Immunol. 173: 6241-7. PMID: 15528362
- Role of CD2 in regulation of CD3- LGL function. | Mason, A., et al. 1991. Eur Cytokine Netw. 2: 31-7. PMID: 1714784
- CD2-associated protein is widely expressed and differentially regulated during embryonic development. | Lehtonen, S., et al. 2008. Differentiation. 76: 506-17. PMID: 18177421
- The coreceptor CD2 uses plasma membrane microdomains to transduce signals in T cells. | Kaizuka, Y., et al. 2009. J Cell Biol. 185: 521-34. PMID: 19398758
- The T-cell CD2 determinant mediates inhibition of erythropoiesis by the lymphokine cascade. | Burdach, S., et al. 1988. Blood. 72: 770-5. PMID: 2456800
- CD2 expression and function in lepromatous leprosy. | Wong, L., et al. 1989. Infect Immun. 57: 2815-9. PMID: 2474503
- Virgin and memory T cells have different requirements for activation via the CD2 molecule. | Byrne, JA., et al. 1989. Int Immunol. 1: 29-35. PMID: 2577287
- Regulation of helper T cell clone proliferation via the CD2 molecule. | Sterkers, G., et al. 1987. Cell Immunol. 109: 192-205. PMID: 2958140
- CD2 and CD3 antigens mobilize Ca2+ independently. | O'Flynn, K., et al. 1986. Eur J Immunol. 16: 580-4. PMID: 3084290
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD2 Antibody (TS2/18) | sc-81732 | 200 µg/ml | $322.00 | |||
CD2 Antibody (TS2/18): m-IgG Fc BP-HRP Bundle | sc-539657 | 200 µg Ab; 10 µg BP | $361.00 | |||
CD2 Antibody (TS2/18): m-IgG1 BP-HRP Bundle | sc-541639 | 200 µg Ab; 20 µg BP | $361.00 | |||
CD2 Antibody (TS2/18) FITC | sc-81732 FITC | 200 µg/ml | $336.00 |