CD2 Antibody (D-5): sc-365017
- CD2 Antibody (D-5) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 319-351 at the C-terminus of CD2 of human origin
- recommended for detection of CD2 of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for CD2 Antibody (D-5) for WB applications. These reagents are now offered in bundles with CD2 Antibody (D-5) (see ordering information below).
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CD2 Antibody (D-5) is a mouse monoclonal IgG1 antibody that detects CD2 in human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CD2 is a crucial transmembrane glycoprotein primarily expressed on peripheral blood T lymphocytes, natural killer (NK) cells, and thymocytes, as well as on mouse B cells and rat splenic macrophages. CD2 mediates cell adhesion by interacting with CD58, which enhances antigen-specific T cell activation. This interaction is vital for optimizing immune system recognition, facilitating communication between helper T lymphocytes and antigen-presenting cells, as well as between cytolytic effectors and target cells. The importance of CD2 in immune responses underscores CD2′s potential as a therapeutic target in various immunological disorders. Anti-CD2 antibody (D-5) provides a reliable tool for researchers studying T cell activation and immune interactions, contributing to a deeper understanding of immune system dynamics.
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CD2 Antibody (D-5) References:
- Mechanism of peripheral T cell activation by coengagement of CD44 and CD2. | Conrad, P., et al. 1992. J Immunol. 149: 1833-9. PMID: 1381388
- The function of the CD2 protein is abnormal in multiple sclerosis. | Reder, AT., et al. 1991. J Autoimmun. 4: 479-91. PMID: 1680333
- Analysis of CD4 and CD2 receptor function. | Goldman, SJ., et al. 1988. Princess Takamatsu Symp. 19: 149-60. PMID: 2908352
- Analysis of monoclonal antibodies reactive with the porcine CD2 antigen. | Pescovitz, MD., et al. 1994. Vet Immunol Immunopathol. 43: 229-32. PMID: 7531904
- Suppression of experimental autoimmune encephalomyelitis in Lewis rats by antibodies against CD2. | Jung, S., et al. 1995. Eur J Immunol. 25: 1391-8. PMID: 7539758
- One sequence, two folds: a metastable structure of CD2. | Murray, AJ., et al. 1995. Proc Natl Acad Sci U S A. 92: 7337-41. PMID: 7638192
- Detection of a glycosylation-dependent ligand for the T lymphocyte cell adhesion molecule CD2 using a novel multimeric recombinant CD2-binding assay. | Parish, CR., et al. 1993. J Immunol. 150: 4833-43. PMID: 7684413
- CD2 ligation abrogates antigen-independent apoptosis in B cells. | Baixeras, E., et al. 1996. Cell Immunol. 171: 55-61. PMID: 8660837
- Signaling via the CD2 receptor enhances HTLV-1 replication in T lymphocytes. | Guyot, DJ., et al. 1997. Virology. 234: 123-9. PMID: 9234953
- The transmembrane region of CD2-associated signal-transducing proteins is crucial for the outcome of CD2-mediated T-cell activation. | Von Bonin, A., et al. 1998. Immunology. 93: 376-82. PMID: 9640248
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD2 Antibody (D-5) | sc-365017 | 200 µg/ml | $322.00 | |||
CD2 Antibody (D-5): m-IgG Fc BP-HRP Bundle | sc-540301 | 200 µg Ab; 10 µg BP | $361.00 | |||
CD2 Antibody (D-5): m-IgG1 BP-HRP Bundle | sc-542024 | 200 µg Ab; 20 µg BP | $361.00 | |||
CD2 (D-5) Neutralizing Peptide | sc-365017 P | 100 µg/0.5 ml | $69.00 |