CD109 Antibody (H-7): sc-365780

CD109 Antibody (H-7) is a mouse monoclonal IgG1 antibody that detects CD109 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CD109 is a glycosylphosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a crucial role in various biological processes, particularly in cancer. CD109 is a member of the α-Macroglobulin/C3, C4, C5 family of thioester-containing proteins and is notably expressed in CD34+ acute myeloid leukemia cell lines, activated T lymphoblasts, activated platelets, T cell lines, endothelial cells, as well as in lung and esophageal squamous cell carcinomas and testis. CD109′s presence in these tissues highlights CD109′s potential as a cancer-testis antigen, which is significant for targeted cancer therapies and diagnostics. Additionally, CD109 carries the platelet-specific Gov antigen system, which is essential in understanding platelet transfusion reactions, neonatal alloimmune thrombocytopenia, and posttransfusion purpura. Anti-CD109 antibody (H-7) effectively identifies and characterizes CD109, making anti-CD109 antibody (H-7) a valuable tool for researchers studying CD109′s implications in hematological malignancies and other related conditions.

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CD109 Antibody (H-7) References:

1. CD109 expression in basal-like breast carcinoma.  |  Hasegawa, M., et al. 2008. Pathol Int. 58: 288-94. PMID: 18429827
2. Processing of CD109 by furin and its role in the regulation of TGF-beta signaling.  |  Hagiwara, S., et al. 2010. Oncogene. 29: 2181-91. PMID: 20101215
3. CD109, a TGF-β co-receptor, attenuates extracellular matrix production in scleroderma skin fibroblasts.  |  Man, XY., et al. 2012. Arthritis Res Ther. 14: R144. PMID: 22694813
4. CD109 plays a role in osteoclastogenesis.  |  Wang, Y., et al. 2013. PLoS One. 8: e61213. PMID: 23593435
5. CD109 attenuates TGF-β1 signaling and enhances EGF signaling in SK-MG-1 human glioblastoma cells.  |  Zhang, JM., et al. 2015. Biochem Biophys Res Commun. 459: 252-258. PMID: 25724945
6. CD109 Restrains Activation of Cutaneous IL-17-Producing γδ T Cells by Commensal Microbiota.  |  Zhang, H., et al. 2019. Cell Rep. 29: 391-405.e5. PMID: 31597099
7. CD109 Is a Critical Determinant of EGFR Expression and Signaling, and Tumorigenicity in Squamous Cell Carcinoma Cells.  |  Zhou, S., et al. 2022. Cancers (Basel). 14: PMID: 35954339
8. Significance of expression of CD109 in osteosarcoma and its involvement in tumor progression via BMP signaling.  |  Mori, N., et al. 2023. Pathol Res Pract. 245: 154443. PMID: 37030166
9. FLOT2 promotes nasopharyngeal carcinoma progression through suppression of TGF-β pathway via facilitating CD109 expression.  |  Xu, H., et al. 2024. iScience. 27: 108580. PMID: 38161417
10. Mechanical force-activated CD109 on periodontal ligament stem cells governs osteogenesis and osteoclast to promote alveolar bone remodeling.  |  Li, Y., et al. 2024. Stem Cells Transl Med. 13: 812-825. PMID: 38885217

The preferred CD109 antibody is CD109 Antibody (C-9): sc-271085.