CD10 Antibody (SN5c/L4-1A1): sc-80544
- CD10 Antibody (SN5c/L4-1A1) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- recommended for detection of CD10 of mouse, rat and human origin by WB, IP, IF and FCM
- See CD10 (F-4): sc-46656 for CD10 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for CD10 Antibody (SN5c/L4-1A1) for WB applications. These reagents are now offered in bundles with CD10 Antibody (SN5c/L4-1A1) (see ordering information below).
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CD10 Antibody (SN5c/L4-1A1) is a mouse monoclonal IgG1 antibody that detects CD10 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). CD10, also known as the common acute lymphoblastic leukemia antigen (CALLA) and neutral endopeptidase (NEP), is a type II integral membrane glycoprotein that plays a crucial role as a zinc metalloprotease, cleaving various biologically active peptides, including Angiotensins I and II. The enzymatic activity of CD10 regulates peptide levels in the extracellular environment, influencing processes such as blood pressure regulation and immune responses. CD10 is predominantly expressed on early B and T lymphoid precursors, B blasts, certain granulocytes, bone marrow stromal cells, and specific epithelial cells, including some tumor cell lines, making CD10 an important marker for diagnosing common acute lymphocytic leukemias and certain lymphomas. Anti-CD10 antibody (SN5c/L4-1A1) versatility in multiple applications enhances research and clinical utility, providing valuable insights into CD10′s role in various biological processes and disease states.
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CD10 Antibody (SN5c/L4-1A1) References:
- Decreased CD10 expression in grade III and in interfollicular infiltrates of follicular lymphomas. | Eshoa, C., et al. 2001. Am J Clin Pathol. 115: 862-7. PMID: 11392883
- CD10 enhances metastasis of colorectal cancer by abrogating the anti-tumoural effect of methionine-enkephalin in the liver. | Kuniyasu, H., et al. 2010. Gut. 59: 348-56. PMID: 19828468
- CD10-bearing fibroblasts may inhibit skin inflammation by down-modulating substance P. | Xie, L., et al. 2011. Arch Dermatol Res. 303: 49-55. PMID: 21076839
- CD10 expressed by fibroblasts and melanoma cells degrades endothelin-1 secreted by human keratinocytes. | Xie, L., et al. 2011. Eur J Dermatol. 21: 505-9. PMID: 21616752
- Tetraspanin protein CD9 interacts with metalloprotease CD10 and enhances its release via exosomes. | Mazurov, D., et al. 2013. FEBS J. 280: 1200-13. PMID: 23289620
- Serum CD10 is associated with liver metastasis in colorectal cancer. | Sasaki, T., et al. 2014. J Surg Res. 192: 390-4. PMID: 24972738
- Immunohistochemical expression and prognostic role of CD10, CD271 and Nestin in primary and recurrent cutaneous melanoma. | Guanziroli, E., et al. 2021. Ital J Dermatol Venerol. 156: 68-72. PMID: 30251808
- Induced CD10 expression during monocyte-to-macrophage differentiation identifies a unique subset of macrophages in pancreatic ductal adenocarcinoma. | Huang, X., et al. 2020. Biochem Biophys Res Commun. 524: 1064-1071. PMID: 32070494
- CD10 and CD34 as markers in vascular malformations with PIK3CA and TEK mutations. | Moneghini, L., et al. 2020. Hum Pathol. 99: 98-106. PMID: 32272124
- A Case of Atypical Hairy Cell Leukemia With CD10+ and CD38+: Diagnosis and Treatment. | Tuan Nguyen, T., et al. 2022. Cureus. 14: e31882. PMID: 36579239
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD10 Antibody (SN5c/L4-1A1) | sc-80544 | 200 µg/ml | $322.00 | |||
CD10 Antibody (SN5c/L4-1A1): m-IgG Fc BP-HRP Bundle | sc-539566 | 200 µg Ab; 10 µg BP | $361.00 | |||
CD10 Antibody (SN5c/L4-1A1): m-IgG1 BP-HRP Bundle | sc-541561 | 200 µg Ab; 20 µg BP | $361.00 |