Yes Antibody (C-4): sc-48396
- Yes Antibody (C-4) is a mouse monoclonal IgG1, cited in 4 publications, provided at 200 µg/ml
- raised against amino acids 1-95 mapping at the N-terminus of c-Yes of human origin
- recommended for detection of c-Yes of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for Yes Antibody (C-4) for WB applications. This reagent is now offered in a bundle with Yes Antibody (C-4) (see ordering information below).
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SEE ALSO...
c-Yes Antibody (C-4) is a mouse monoclonal IgG1 antibody that detects c-Yes in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). c-Yes is a crucial member of the Src family of non-receptor tyrosine kinases, which play a significant role in various cellular processes, including proliferation, differentiation, motility, and adhesion. c-Yes is primarily located in the cytoplasm and translocates to the cell membrane upon activation, where c-Yes interacts with various signaling pathways. This localization enables c-Yes to modulate cellular responses to external stimuli, thereby influencing critical processes such as cell growth and survival. The c-Yes gene, which maps to chromosome 18p11.31-p11.21, encodes a 543 amino acid protein that shares over 80% homology with c-Src outside of their unique amino-termini, highlighting the evolutionary conservation and functional importance of these kinases. anti-c-Yes antibody (C-4) provides reliable detection and analysis of c-Yes, facilitating research into its role in oncogenic signaling and potential therapeutic targets in cancer biology.
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Yes Antibody (C-4) References:
- Yes-associated protein 65 localizes p62(c-Yes) to the apical compartment of airway epithelia by association with EBP50. | Mohler, PJ., et al. 1999. J Cell Biol. 147: 879-90. PMID: 10562288
- Association of nonreceptor tyrosine kinase c-yes with tight junction protein occludin by coimmunoprecipitation assay. | Chen, YH. and Lu, Q. 2003. Methods Mol Biol. 218: 127-32. PMID: 12616717
- The Src family kinase c-Yes is required for maturation of West Nile virus particles. | Hirsch, AJ., et al. 2005. J Virol. 79: 11943-51. PMID: 16140770
- c-Yes response to growth factor activation. | Clump, DA., et al. 2005. Growth Factors. 23: 263-72. PMID: 16338789
- Elevated c-Src and c-Yes expression in malignant skin cancers. | Lee, JH., et al. 2010. J Exp Clin Cancer Res. 29: 116. PMID: 20796316
- c-Yes regulates cell adhesion at the apical ectoplasmic specialization-blood-testis barrier axis via its effects on protein recruitment and distribution. | Xiao, X., et al. 2013. Am J Physiol Endocrinol Metab. 304: E145-59. PMID: 23169788
- C-Src and c-Yes are two unlikely partners of spermatogenesis and their roles in blood-testis barrier dynamics. | Xiao, X., et al. 2012. Adv Exp Med Biol. 763: 295-317. PMID: 23397631
- An iterative compound screening contest method for identifying target protein inhibitors using the tyrosine-protein kinase Yes. | Chiba, S., et al. 2017. Sci Rep. 7: 12038. PMID: 28931921
- Association of the polyomavirus middle-T antigen with c-yes protein. | Kornbluth, S., et al. Nature. 325: 171-3. PMID: 3027584
- Molecular cloning and analysis of cDNA encoding the murine c-yes tyrosine protein kinase. | Klages, S., et al. 1993. Oncogene. 8: 713-9. PMID: 8437854
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Yes Antibody (C-4) | sc-48396 | 200 µg/ml | $322.00 | |||
Yes Antibody (C-4): m-IgG Fc BP-HRP Bundle | sc-551930 | 200 µg Ab; 10 µg BP | $361.00 |