Myc Antibody (6A10): sc-53854
- Myc Antibody (6A10) is a rat monoclonal IgG2a, cited in 6 publications, provided at 200 µg/ml
- raised against amino acids 1-262 of c-Myc of human origin
- recommended for detection of c-Myc of mouse, rat, human and monkey origin by WB, IP and IF
- See Myc (9E10): sc-40 for Myc antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Myc Antibody (6A10). This work is in progress.
c-Myc Antibody (6A10) is a rat monoclonal IgG2a antibody raised against amino acids 1-262 of human c-Myc. c-Myc rat monoclonal antibody (6A10) recognizes an epitope within the N-terminal region and demonstrates effectiveness in Western blotting, immunofluorescence, and immunoprecipitation applications. Anti-c-Myc monoclonal antibody (6A10) serves as a valuable tool for investigating c-Myc expression, regulation, and activity in various tissues and disease models. The c-Myc protein is a highly conserved transcription factor central to regulating key cellular processes such as proliferation, differentiation, metabolism, and apoptosis. As a member of the Myc family, which includes N-Myc and L-Myc, c-Myc plays a critical role in controlling the expression of genes involved in cell cycle progression, particularly during the G1 to S phase transition, as well as genes regulating cellular growth and metabolism. c-Myc functions through a basic helix-loop-helix leucine zipper (bHLH-Zip) domain, which enables heterodimerization with Max protein, an essential partner that allows c-Myc to bind specific DNA sequences known as E-box motifs (CACGTG). The c-Myc/Max complex acts as a key regulator of transcription, modulating the expression of numerous genes that drive cellular growth and division. In normal cellular function, c-Myc undergoes tight regulation to ensure proper cell cycle control and balanced cell growth. However, dysregulation or overexpression of c-Myc, often through gene amplification or chromosomal translocation, frequently occurs in cancers such as lung, breast, and colon carcinomas, contributing to uncontrolled cell proliferation, resistance to apoptosis, and neoplastic disease development. c-Myc (6A10) antibody recognition of the N-terminal region makes the antibody particularly useful for studying c-Myc′s role in cellular processes and dysregulation in cancer. c-Myc monoclonal antibody (6A10) proves essential for advancing the understanding of c-Myc′s involvement in oncogenic pathways, post-translational modifications, and the development of potential therapeutic interventions for c-Myc-driven cancers.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Myc Antibody (6A10) | sc-53854 | 200 µg/ml | $322.00 |