BRD2 Antibody (A-2): sc-514103

BRD2 Antibody (A-2) is a mouse monoclonal IgG1 antibody that detects BRD2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). BRD2, also known as RING3 protein, plays a crucial role as a mitogen-activated nuclear protein, which is essential for regulating gene expression in response to cellular signals. BRD2 gene is located in the human major histocompatibility complex (MHC) class II region, linking BRD2 to HLA-associated diseases and highlighting BRD2′s importance in immune response and potential implications in autoimmune disorders. BRD2′s ability to interact with various transcription factors and chromatin remodeling complexes underscores BRD2′s significance in cellular processes such as proliferation and differentiation. Furthermore, BRD2 is part of a larger family of bromodomain-containing proteins, which are known for their role in recognizing acetylated lysines on histones and non-histone proteins, thereby influencing chromatin structure and gene expression. BRD2 (A-2) antibody is a valuable tool for researchers investigating the molecular mechanisms underlying these processes and their implications in health and disease.

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BRD2 Antibody (A-2) References:

1. Brd2 is a TBP-associated protein and recruits TBP into E2F-1 transcriptional complex in response to serum stimulation.  |  Peng, J., et al. 2007. Mol Cell Biochem. 294: 45-54. PMID: 17111193
2. The chromatin-targeting protein Brd2 is required for neural tube closure and embryogenesis.  |  Gyuris, A., et al. 2009. Biochim Biophys Acta. 1789: 413-21. PMID: 19362612
3. The bromodomain-containing gene BRD2 is regulated at transcription, splicing, and translation levels.  |  Shang, E., et al. 2011. J Cell Biochem. 112: 2784-93. PMID: 21608014
4. The C-terminal domain of Brd2 is important for chromatin interaction and regulation of transcription and alternative splicing.  |  Hnilicová, J., et al. 2013. Mol Biol Cell. 24: 3557-68. PMID: 24048450
5. LYAR potentiates rRNA synthesis by recruiting BRD2/4 and the MYST-type acetyltransferase KAT7 to rDNA.  |  Izumikawa, K., et al. 2019. Nucleic Acids Res. 47: 10357-10372. PMID: 31504794
6. LAMB3 promotes tumour progression through the AKT-FOXO3/4 axis and is transcriptionally regulated by the BRD2/acetylated ELK4 complex in colorectal cancer.  |  Zhu, Z., et al. 2020. Oncogene. 39: 4666-4680. PMID: 32398865
7. Brd2/4 and Myc regulate alternative cell lineage programmes during early osteoclast differentiation in vitro.  |  Caputo, VS., et al. 2021. iScience. 24: 101989. PMID: 33490899
8. BRD2 protects the rat H9C2 cardiomyocytes from hypoxia‑reoxygenation injury by targeting Nrf2/HO‑1 signaling pathway.  |  Liu, Y., et al. 2023. Exp Ther Med. 26: 542. PMID: 37869639
9. miR-143 promotes cell proliferation, invasion and migration via directly binding to BRD2 in lens epithelial cells.  |  Chen, Y., et al. 2024. Am J Transl Res. 16: 446-457. PMID: 38463605
10. YEATS domain-containing protein GAS41 regulates nuclear shape by working in concert with BRD2 and the mediator complex in colorectal cancer.  |  Wang, Z., et al. 2024. Pharmacol Res. 206: 107283. PMID: 38964523

The preferred BRD2 antibody is BRD2 Antibody (G-4): sc-393720.