Molecular structure of BMS 753, CAS Number: 215307-86-1
BMS 753 (CAS 215307-86-1)
Alternate Names:
4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid
Application:
BMS 753 is as been reported to be a RARα-selective agonist
CAS Number:
215307-86-1
Purity:
≥98%
Molecular Weight:
351.40
Molecular Formula:
C21H21NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
BMS 753 has been reported to be a RARα-selective agonist.
BMS 753 (CAS 215307-86-1) References
- Ligand-dependent activation of transcription in vitro by retinoic acid receptor alpha/retinoid X receptor alpha heterodimers that mimics transactivation by retinoids in vivo. | Dilworth, FJ., et al. 1999. Proc Natl Acad Sci U S A. 96: 1995-2000. PMID: 10051583
- Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists. | Géhin, M., et al. 1999. Chem Biol. 6: 519-29. PMID: 10421757
- Retinoic acid induces proteasome-dependent degradation of retinoic acid receptor alpha (RARalpha) and oncogenic RARalpha fusion proteins. | Zhu, J., et al. 1999. Proc Natl Acad Sci U S A. 96: 14807-12. PMID: 10611294
- Synthetic retinoids dissociate coactivator binding from corepressor release. | Zechel, C. 2002. J Recept Signal Transduct Res. 22: 31-61. PMID: 12503607
- Regulation of CYP26A1 expression by selective RAR and RXR agonists in human NB4 promyelocytic leukemia cells. | Idres, N., et al. 2005. Biochem Pharmacol. 69: 1595-601. PMID: 15896339
- Distinct roles for retinoic acid receptors alpha and beta in early lung morphogenesis. | Desai, TJ., et al. 2006. Dev Biol. 291: 12-24. PMID: 16427040
- Commitment of mouse embryonic stem cells to the adipocyte lineage requires retinoic acid receptor beta and active GSK3. | Monteiro, MC., et al. 2009. Stem Cells Dev. 18: 457-63. PMID: 18690793
- All-trans retinoic acid suppresses interleukin-6 expression in interleukin-1-stimulated synovial fibroblasts by inhibition of ERK1/2 pathway independently of RAR activation. | Kirchmeyer, M., et al. 2008. Arthritis Res Ther. 10: R141. PMID: 19068145
- Lipid Abundance in Zebrafish Embryos Is Regulated by Complementary Actions of the Endocannabinoid System and Retinoic Acid Pathway. | Fraher, D., et al. 2015. Endocrinology. 156: 3596-609. PMID: 26181105
- The Retinoid Agonist Tazarotene Promotes Angiogenesis and Wound Healing. | Al Haj Zen, A., et al. 2016. Mol Ther. 24: 1745-1759. PMID: 27480772
- Diencephalic Size Is Restricted by a Novel Interplay Between GCN5 Acetyltransferase Activity and Retinoic Acid Signaling. | Wilde, JJ., et al. 2017. J Neurosci. 37: 2565-2579. PMID: 28154153
- Combination of yeast-based in vitro screens with high-performance thin-layer chromatography as a novel tool for the detection of hormonal and dioxin-like compounds. | Riegraf, C., et al. 2019. Anal Chim Acta. 1081: 218-230. PMID: 31446961
- Improved Atrial Differentiation of Human Pluripotent Stem Cells by Activation of Retinoic Acid Receptor Alpha (RARα). | Schwach, V., et al. 2022. J Pers Med. 12: PMID: 35455744
- Molecular and electrophysiological evaluation of human cardiomyocyte subtypes to facilitate generation of composite cardiac models. | Li, J., et al. 2022. J Tissue Eng. 13: 20417314221127908. PMID: 36277058
- Cell-type and promoter-context dependent retinoic acid receptor (RAR) redundancies for RAR beta 2 and Hoxa-1 activation in F9 and P19 cells can be artefactually generated by gene knockouts. | Taneja, R., et al. 1996. Proc Natl Acad Sci U S A. 93: 6197-202. PMID: 8650243
Activator of:
RAR alpha.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BMS 753, 5 mg | sc-361125 | 5 mg | $141.00 | |||
BMS 753, 25 mg | sc-361125A | 25 mg | $406.00 |