Bcl-B Antibody (3B4): sc-134279

Bcl-B Antibody (3B4) is a mouse monoclonal IgG2b kappa light chain antibody that detects the Bcl-B protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Bcl-B antibody (3B4) is available as the non-conjugated format. Bcl-B, also known as BCL2L10, Diva, Boo, or BCLB, is a crucial member of the Bcl-2 family of proteins, consisting of 194 amino acids and widely expressed in various tissues. Bcl-B (3B4) antibody recognizes a protein that plays a vital role in regulating cell survival by inhibiting apoptosis, which is essential for maintaining cellular homeostasis and preventing excessive cell death. Bcl-B is localized to the nuclear membrane, where Bcl-B (3B4) monoclonal antibody detects its anti-apoptotic effects in suppressing BAX-induced apoptosis. Bcl-B contains a BH4 domain and a transmembrane domain, both critical for its function in promoting cell survival. Notably, overexpression of Bcl-B has been linked to the prevention of cytochrome C release from the mitochondria, a key event that triggers caspase-3 activation and leads to apoptosis. Furthermore, Bcl-B is implicated in the pathogenesis of cervical cancer, highlighting its significance in cancer biology and potential as a therapeutic target.

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Bcl-B Antibody (3B4) References:

1. Bcl-B, a novel Bcl-2 family member that differentially binds and regulates Bax and Bak.  |  Ke, N., et al. 2001. J Biol Chem. 276: 12481-4. PMID: 11278245
2. Characterization of NR13-related human cell death regulator, Boo/Diva, in normal and cancer tissues.  |  Lee, R., et al. 2001. Biochim Biophys Acta. 1520: 187-94. PMID: 11566354
3. Bcl-2-related protein family gene expression during oligodendroglial differentiation.  |  Itoh, T., et al. 2003. J Neurochem. 85: 1500-12. PMID: 12787069
4. Alteration in copy numbers of genes as a mechanism for acquired drug resistance.  |  Yasui, K., et al. 2004. Cancer Res. 64: 1403-10. PMID: 14973057
5. Analysis of genes upregulated by the demethylating agent 5-aza-2'-deoxycytidine in gastric cancer cell lines.  |  Mikata, R., et al. 2006. Int J Cancer. 119: 1616-22. PMID: 16671088
6. NM23-H2 involves in negative regulation of Diva and Bcl2L10 in apoptosis signaling.  |  Kang, Y., et al. 2007. Biochem Biophys Res Commun. 359: 76-82. PMID: 17532299
7. mRNA expression of Bcl-2, Bax, caspase-3 and -7 cannot be used as a marker for apoptosis in bovine blastocysts.  |  Vandaele, L., et al. 2008. Anim Reprod Sci. 106: 168-73. PMID: 18272300