Bcl-2 Antibody (12): sc-130307
- Bcl-2 Antibody (12) is a mouse monoclonal IgG2a κ, cited in 21 publications, provided at 200 µg/ml
- raised against recombinant Bcl-2 of human origin
- recommended for detection of Bcl-2 of human origin by WB, IP and ELISA
- See Bcl-2 (C-2): sc-7382 for Bcl-2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Bcl-2 Antibody (12) for WB applications. These reagents are now offered in bundles with Bcl-2 Antibody (12) (see ordering information below).
QUICK LINKS
SEE ALSO...
Bcl-2 Antibody (12) is a mouse monoclonal IgG2a antibody that detects Bcl-2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Bcl-2 is a crucial anti-apoptotic protein that plays a significant role in regulating apoptosis, which is vital for maintaining tissue homeostasis and protecting against diseases, including cancer. Located primarily in the outer mitochondrial membrane, anti-Bcl-2 antibody (12) targets a protein whose strategic positioning allows effective inhibition of pro-apoptotic factor release, thereby preventing cell death. This localization is essential because Bcl-2 interacts with other members of the Bcl-2 family, such as Bax and Bak, which are key players in the apoptotic pathway. By stabilizing the mitochondrial membrane, Bcl-2 not only promotes cell survival but also contributes to the overall balance between cell death and proliferation, a process that, when disrupted, can lead to tumorigenesis. Bcl-2 monoclonal antibody (12) serves as an invaluable tool for researchers studying the mechanisms of apoptosis and the implications of Bcl-2 in various diseases, particularly in understanding how dysregulation can lead to cancer progression.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Bcl-2 Antibody (12) References:
- Bcl-2 and Ca2+ homeostasis in the endoplasmic reticulum. | Pinton, P. and Rizzuto, R. 2006. Cell Death Differ. 13: 1409-18. PMID: 16729032
- BCL-2 is dispensable for thrombopoiesis and platelet survival. | Debrincat, MA., et al. 2015. Cell Death Dis. 6: e1721. PMID: 25880088
- Locating Herpesvirus Bcl-2 Homologs in the Specificity Landscape of Anti-Apoptotic Bcl-2 Proteins. | Foight, GW. and Keating, AE. 2015. J Mol Biol. 427: 2468-2490. PMID: 26009469
- Inhibition and conformational change of SERCA3b induced by Bcl-2. | Hewarathna, A., et al. 2017. Biochim Biophys Acta Proteins Proteom. 1865: 121-131. PMID: 27639965
- Breaking through BCL-2 inhibition in CLL. | Chong, SJF. and Davids, MS. 2020. Blood. 135: 709-711. PMID: 32135019
- Therapeutic development and current uses of BCL-2 inhibition. | Roberts, AW. 2020. Hematology Am Soc Hematol Educ Program. 2020: 1-9. PMID: 33275682
- BCL-2 Inhibition as Treatment for Chronic Lymphocytic Leukemia. | Perini, GF., et al. 2021. Curr Treat Options Oncol. 22: 66. PMID: 34110507
- Bim transfer between Bcl-2-like protein and Hsp70 underlines Bcl-2/Hsp70 crosstalk to regulate apoptosis. | Zhang, H., et al. 2021. Biochem Pharmacol. 190: 114660. PMID: 34153292
- Circulating Bcl-2 concentrations and septic patient mortality. | Lorente, L., et al. 2021. Enferm Infecc Microbiol Clin (Engl Ed). 39: 330-334. PMID: 34353509
- Novel BH4-BCL-2 Domain Antagonists Induce BCL-2-Mediated Apoptosis in Triple-Negative Breast Cancer. | Kanakaveti, V., et al. 2022. Cancers (Basel). 14: PMID: 36358660
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bcl-2 Antibody (12) | sc-130307 | 200 µg/ml | $322.00 | |||
Bcl-2 Antibody (12): m-IgG Fc BP-HRP Bundle | sc-537318 | 200 µg Ab; 10 µg BP | $361.00 | |||
Bcl-2 Antibody (12): m-IgGκ BP-HRP Bundle | sc-534556 | 200 µg Ab; 40 µg BP | $361.00 | |||
Bcl-2 Antibody (12): m-IgG2a BP-HRP Bundle | sc-547977 | 200 µg Ab; 10 µg BP | $361.00 |